Identification of RAD51-BRCA2 Inhibitors Using
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
11 Aug 2022
11 Aug 2022
Historique:
received:
15
02
2022
accepted:
22
07
2022
entrez:
18
8
2022
pubmed:
19
8
2022
medline:
19
8
2022
Statut:
epublish
Résumé
RAD51 is an ATP-dependent recombinase, recruited by BRCA2 to mediate DNA double-strand breaks repair through homologous recombination and represents an attractive cancer drug target. Herein, we applied for the first-time protein-templated dynamic combinatorial chemistry on RAD51 as a hit identification strategy. Upon design of
Identifiants
pubmed: 35978685
doi: 10.1021/acsmedchemlett.2c00063
pmc: PMC9377020
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1262-1269Informations de copyright
© 2022 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
ACS Med Chem Lett. 2020 Feb 28;11(5):1041-1046
pubmed: 32435423
Nat Rev Drug Discov. 2002 Jan;1(1):26-36
pubmed: 12119606
Nature. 2002 Nov 21;420(6913):287-93
pubmed: 12442171
Chemistry. 2019 Jan 2;25(1):60-73
pubmed: 30204930
Drug Discov Today. 2009 Nov;14(21-22):1051-7
pubmed: 19716431
ACS Omega. 2020 Oct 08;5(41):26307-26315
pubmed: 33110958
Cancer Treat Rev. 2015 Jan;41(1):35-45
pubmed: 25467108
Drug Discov Today. 2000 Feb;5(2):67-75
pubmed: 10652457
N Engl J Med. 2019 Jul 25;381(4):317-327
pubmed: 31157963
ACS Chem Biol. 2017 Oct 20;12(10):2491-2497
pubmed: 28841282
European J Org Chem. 2019 Jun 16;2019(22):3581-3590
pubmed: 31680778
Nucleic Acids Res. 2010 Jan;38(1):82-96
pubmed: 19875419
ChemMedChem. 2018 Nov 6;13(21):2266-2270
pubmed: 30178575
Eur J Med Chem. 2019 Mar 1;165:80-92
pubmed: 30660828
Chem Sci. 2021 Apr 28;12(22):7775-7785
pubmed: 34168831
Genes (Basel). 2018 Dec 13;9(12):
pubmed: 30551670
Nat Chem. 2010 Jun;2(6):490-7
pubmed: 20489719
Drugs. 2015 Feb;75(2):231-40
pubmed: 25616434
Chem Soc Rev. 2015 Apr 21;44(8):2455-88
pubmed: 25706945
DNA Repair (Amst). 2008 May 3;7(5):686-93
pubmed: 18243065
Cell Chem Biol. 2021 Jun 17;28(6):835-847.e5
pubmed: 33662256
ChemMedChem. 2016 Nov 21;11(22):2468-2473
pubmed: 27781374
J Med Chem. 2020 Mar 12;63(5):2588-2619
pubmed: 32037829
Biochim Biophys Acta Rev Cancer. 2021 Dec;1876(2):188597
pubmed: 34332021
Oncologist. 2021 Jan;26(1):e164-e172
pubmed: 33017510
Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20810-5
pubmed: 19106292