Cypermethrin Toxicity-induced Infertility: An Assessment of Longitudinal Transfer of Protective Potentials of Date Fruit Extracts in Wister Rats.
Fertility
Wistar rats
cypermethrin
date fruit
male rat
sex ratio
Journal
Recent patents on biotechnology
ISSN: 2212-4012
Titre abrégé: Recent Pat Biotechnol
Pays: United Arab Emirates
ID NLM: 101309942
Informations de publication
Date de publication:
2023
2023
Historique:
received:
19
02
2022
revised:
06
05
2022
accepted:
23
05
2022
medline:
16
5
2023
pubmed:
19
8
2022
entrez:
18
8
2022
Statut:
ppublish
Résumé
There is a potential for longitudinal and horizontal transfer of the cytotoxic effects of cypermethrin, and evidence suggests that date fruit extracts can ameliorate these cytotoxic effects. Thus, the current study evaluated female Wister rats' fertility and pup parameters after mating males treated with cypermethrin and date fruit (Phoenix dactylifera) extract. Adult Wistar rats (n = 74; 140 - 207 g) were used to conduct this experiment in two phases: The first phase was a single dose toxicity study (n = 18), while the second phase (n = 56) evaluated female Wister rats' reproductive and pup development parameters after mating with male Wistar rats exposed to date fruit extract and cypermethrin. Male rats were distributed randomly into four groups (n = 7 per group) and administered distilled water (Group I); 60 mg/kg cypermethrin (Group II) to simulate infertility; 250 mg/kg date fruit extract alone (Group III); and date fruit extracts plus 60 mg/kg cypermethrin (Group IV). Treated males were then mated with healthy female rats at a ratio of 1:1. Successfully mated females were appraised for conception and pregnancy rates, gestation length, litter size, and weights at birth, and on days 5, 10, 15, and 21 post-partum, an anogenital distance at day-20, sex ratio, and age of pup when hair growth was evident. Significant differences (p < 0.05) were observed in litter size and male anogenital distance but not in reproductive performance. Also, the study demonstrated that date fruit extract skewed the sex ratio of offspring to more female than male pups when female Wister rats were mated with males that received date fruit extracts alone or cypermethrin and date fruit extracts. The body weight gain did not differ significantly between the control and cypermethrin-treated groups. This evidence suggested a longitudinal transfer of the protective effects of date fruit extracts following a weekly exposure of male rats to cypermethrin at 60 mg/kg.
Sections du résumé
BACKGROUND
BACKGROUND
There is a potential for longitudinal and horizontal transfer of the cytotoxic effects of cypermethrin, and evidence suggests that date fruit extracts can ameliorate these cytotoxic effects. Thus, the current study evaluated female Wister rats' fertility and pup parameters after mating males treated with cypermethrin and date fruit (Phoenix dactylifera) extract.
METHODS
METHODS
Adult Wistar rats (n = 74; 140 - 207 g) were used to conduct this experiment in two phases: The first phase was a single dose toxicity study (n = 18), while the second phase (n = 56) evaluated female Wister rats' reproductive and pup development parameters after mating with male Wistar rats exposed to date fruit extract and cypermethrin. Male rats were distributed randomly into four groups (n = 7 per group) and administered distilled water (Group I); 60 mg/kg cypermethrin (Group II) to simulate infertility; 250 mg/kg date fruit extract alone (Group III); and date fruit extracts plus 60 mg/kg cypermethrin (Group IV). Treated males were then mated with healthy female rats at a ratio of 1:1. Successfully mated females were appraised for conception and pregnancy rates, gestation length, litter size, and weights at birth, and on days 5, 10, 15, and 21 post-partum, an anogenital distance at day-20, sex ratio, and age of pup when hair growth was evident.
RESULTS
RESULTS
Significant differences (p < 0.05) were observed in litter size and male anogenital distance but not in reproductive performance. Also, the study demonstrated that date fruit extract skewed the sex ratio of offspring to more female than male pups when female Wister rats were mated with males that received date fruit extracts alone or cypermethrin and date fruit extracts. The body weight gain did not differ significantly between the control and cypermethrin-treated groups.
CONCLUSION
CONCLUSIONS
This evidence suggested a longitudinal transfer of the protective effects of date fruit extracts following a weekly exposure of male rats to cypermethrin at 60 mg/kg.
Identifiants
pubmed: 35980049
pii: BIOT-EPUB-125520
doi: 10.2174/1872208316666220817092827
doi:
Substances chimiques
cypermethrin
1TR49121NP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
176-185Informations de copyright
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