Repurposing the Ionophore, PBT2, for Treatment of Multidrug-Resistant Neisseria gonorrhoeae Infections.
Neisseria gonorrhoeae
Neisseria meningitidis
PBT2
antibiotic resistance
gonorrhoea
ionophore
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
20 09 2022
20 09 2022
Historique:
pubmed:
19
8
2022
medline:
24
9
2022
entrez:
18
8
2022
Statut:
ppublish
Résumé
Multidrug-resistant (MDR) N. gonorrhoeae is a current public health threat. New therapies are urgently needed. PBT2 is an ionophore that disrupts metal homeostasis. PBT2 administered with zinc is shown to reverse resistance to antibiotics in several bacterial pathogens. Here we show that both N. meningitidis and MDR N. gonorrhoeae are sensitive to killing by PBT2 alone. PBT2 is, thus, a candidate therapeutic for MDR N. gonorrhoeae infections.
Identifiants
pubmed: 35980187
doi: 10.1128/aac.02318-21
pmc: PMC9487457
doi:
Substances chimiques
Anti-Bacterial Agents
0
Ionophores
0
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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