Eccentric muscle contraction potentiates titin stiffness-related contractile properties in rat fast-twitch muscles.

Animals Calcium / metabolism Connectin / metabolism Muscle Contraction / physiology Muscle, Skeletal / physiology Myofibrils / metabolism Rats
length-dependent activation molecular spring muscle damage passive force sarcomere stretch

Journal

Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601
Titre abrégé: J Appl Physiol (1985)
Pays: United States
ID NLM: 8502536

Informations de publication

Date de publication:
01 09 2022
Historique:
pubmed: 19 8 2022
medline: 15 9 2022
entrez: 18 8 2022
Statut: ppublish

Résumé

This study was conducted to examine the effects of an acute bout of eccentric muscle contraction (ECC) on titin stiffness-related contractile properties in rat fast-twitch skeletal muscles. Intact gastrocnemius muscles were electrically stimulated in situ to undergo 200 repeated ECCs. Immediately after the cessation of the stimulation, the superficial regions of the muscles were dissected and subjected to biochemical and skinned fiber analyses. Small heat shock protein αB-crystallin in the muscle fraction enriched for myofibrillar proteins was increased by ECC. ECC resulted in an increase in the titin-based passive force. Protein kinase A-treatment decreased the passive force only in ECC-subjected but not in rested fibers. ECC decreased the maximum Ca

Identifiants

DOI: 10.1152/japplphysiol.00327.2022 PMID: 35981734
pubmed: 35981734
doi: 10.1152/japplphysiol.00327.2022
doi:

Substances chimiques

Connectin 0
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

710-720

Subventions

Organisme : Grants-in-Aid for Scientic Research of Japan
ID : 20K11335

Auteurs

Jiayu Shi (J)

Graduate School of Integrated Arts and Sciences, Hiroshima University, Hiroshima, Japan.

Daiki Watanabe (D)

Graduate School of Humanities and Social Sciences, Hiroshima University, Hiroshima, Japan.
ORCID: 0000-0002-1278-3773

Masanobu Wada (M)

Graduate School of Integrated Arts and Sciences, Hiroshima University, Hiroshima, Japan.
Graduate School of Humanities and Social Sciences, Hiroshima University, Hiroshima, Japan.
ORCID: 0000-0002-6628-0848

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Eccentric muscle contraction potentiates titin...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Eccentric muscle contraction potentiates titin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines contractiles › Protéines du muscle › Connectine › Eccentric muscle contraction potentiates titin...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Contraction musculaire › Eccentric muscle contraction potentiates titin...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › Eccentric muscle contraction potentiates titin...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Myofibrilles › Eccentric muscle contraction potentiates titin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Eccentric muscle contraction potentiates titin...