Cognitive deficits, clinical variables, and white matter microstructure in schizophrenia: a multisite harmonization study.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
11
02
2022
accepted:
29
07
2022
revised:
18
07
2022
pubmed:
19
8
2022
medline:
2
12
2022
entrez:
18
8
2022
Statut:
ppublish
Résumé
Cognitive deficits are among the best predictors of real-world functioning in schizophrenia. However, our understanding of how cognitive deficits relate to neuropathology and clinical presentation over the disease lifespan is limited. Here, we combine multi-site, harmonized cognitive, imaging, demographic, and clinical data from over 900 individuals to characterize a) cognitive deficits across the schizophrenia lifespan and b) the association between cognitive deficits, clinical presentation, and white matter (WM) microstructure. Multimodal harmonization was accomplished using T-scores for cognitive data, previously reported standardization methods for demographic and clinical data, and an established harmonization method for imaging data. We applied t-tests and correlation analysis to describe cognitive deficits in individuals with schizophrenia. We then calculated whole-brain WM fractional anisotropy (FA) and utilized regression-mediation analyses to model the association between diagnosis, FA, and cognitive deficits. We observed pronounced cognitive deficits in individuals with schizophrenia (p < 0.006), associated with more positive symptoms and medication dosage. Regression-mediation analyses showed that WM microstructure mediated the association between schizophrenia and language/processing speed/working memory/non-verbal memory. In addition, processing speed mediated the influence of diagnosis and WM microstructure on the other cognitive domains. Our study highlights the critical role of cognitive deficits in schizophrenia. We further show that WM is crucial when trying to understand the role of cognitive deficits, given that it explains the association between schizophrenia and cognitive deficits (directly and via processing speed).
Identifiants
pubmed: 35982257
doi: 10.1038/s41380-022-01731-3
pii: 10.1038/s41380-022-01731-3
pmc: PMC10538303
mid: NIHMS1926901
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3719-3730Subventions
Organisme : NIMH NIH HHS
ID : R01 MH102377
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH102324
Pays : United States
Organisme : NIMH NIH HHS
ID : K24 MH110807
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH077862
Pays : United States
Organisme : CSRD VA
ID : I01 CX000176
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH102318
Pays : United States
Organisme : NIMH NIH HHS
ID : R03 MH110745
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH119222
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH076995
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH080173
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH077851
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH109977
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH077945
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH108574
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH115247
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH078113
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH108654
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH092440
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Limited.
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