Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB 1.0): development and normative data.

Alzheimer’s disease Cognition Neuropsychological tests UDS

Journal

Alzheimer's research & therapy
ISSN: 1758-9193
Titre abrégé: Alzheimers Res Ther
Pays: England
ID NLM: 101511643

Informations de publication

Date de publication:
19 08 2022
Historique:
received: 29 05 2022
accepted: 18 07 2022
entrez: 18 8 2022
pubmed: 19 8 2022
medline: 23 8 2022
Statut: epublish

Résumé

Neuropsychological testing plays a cardinal role in the diagnosis and monitoring of Alzheimer's disease. A major concern is represented by the heterogeneity of the neuropsychological batteries currently adopted in memory clinics and healthcare centers. The current study aimed to solve this issue. Following the initiative of the University of Washington's National Alzheimer's Coordinating Center (NACC), we presented the Italian adaptation of the Neuropsychological Test Battery of the Uniform Data Set (I-UDSNB). We collected data from 433 healthy Italian individuals and employed regression models to evaluate the impact of demographic variables on the performance, deriving the reference norms. Higher education and lower age were associated with a better performance in the majority of tests, while sex affected only fluency tests and Digit Span Forward. The I-UDSNB offers a valuable and harmonized tool for neuropsychological testing in Italy, to be used in clinical and research settings.

Sections du résumé

BACKGROUND
Neuropsychological testing plays a cardinal role in the diagnosis and monitoring of Alzheimer's disease. A major concern is represented by the heterogeneity of the neuropsychological batteries currently adopted in memory clinics and healthcare centers. The current study aimed to solve this issue.
METHODS
Following the initiative of the University of Washington's National Alzheimer's Coordinating Center (NACC), we presented the Italian adaptation of the Neuropsychological Test Battery of the Uniform Data Set (I-UDSNB). We collected data from 433 healthy Italian individuals and employed regression models to evaluate the impact of demographic variables on the performance, deriving the reference norms.
RESULTS
Higher education and lower age were associated with a better performance in the majority of tests, while sex affected only fluency tests and Digit Span Forward.
CONCLUSIONS
The I-UDSNB offers a valuable and harmonized tool for neuropsychological testing in Italy, to be used in clinical and research settings.

Identifiants

pubmed: 35982477
doi: 10.1186/s13195-022-01056-x
pii: 10.1186/s13195-022-01056-x
pmc: PMC9389755
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

113

Subventions

Organisme : NIA NIH HHS
ID : P30 AG072977
Pays : United States

Commentaires et corrections

Type : ErratumIn
Type : ErratumIn

Informations de copyright

© 2022. The Author(s).

Références

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Auteurs

Francesca Conca (F)

IRCCS Mondino Foundation, Pavia, Italy.

Valentina Esposito (V)

IRCCS Mondino Foundation, Pavia, Italy.

Francesco Rundo (F)

Department of Neurology IC, Oasi Research Institute - IRCCS, Troina, Italy.

Davide Quaranta (D)

Neurology Unit, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
Department of Psychology, Catholic University of the Sacred Heart, Milan, Italy.

Cristina Muscio (C)

Present address: ASST Bergamo Ovest, Treviglio, Italy.
Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

Rosa Manenti (R)

IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.

Giulia Caruso (G)

Laboratory of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.

Ugo Lucca (U)

Laboratory of Geriatric Neuropsychiatry, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.

Alessia Antonella Galbussera (AA)

Laboratory of Geriatric Neuropsychiatry, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.

Sonia Di Tella (S)

IRCCS Fondazione Don Carlo Gnocchi, ONLUS, Milan, Italy.

Francesca Baglio (F)

IRCCS Fondazione Don Carlo Gnocchi, ONLUS, Milan, Italy.

Federica L'Abbate (F)

Neurology Unit, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.

Elisa Canu (E)

Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Valentina Catania (V)

Unit of Psychology I.C., Oasi Research Institute-IRCCS, Troina, Italy.

Massimo Filippi (M)

Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Neurology Unit, Neurorehabilitation Unit, and Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

Giulia Mattavelli (G)

IUSS Cognitive Neuroscience (ICON) Center, Scuola Universitaria Superiore IUSS, Palazzo del Broletto, Piazza Vittoria 15, 27100, Pavia, Italy.
Istituti Clinici Scientifici Maugeri IRCCS, Cognitive Neuroscience Laboratory of Pavia Institute, Pavia, Italy.

Barbara Poletti (B)

Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.

Vincenzo Silani (V)

Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.
Aldo Ravelli Research Center for Neurotechnology and Experimental Brain Therapeutics, Università degli studi di Milano, Milan, Italy.

Raffaele Lodi (R)

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.

Maddalena De Matteis (M)

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.

Michelangelo Stanzani Maserati (M)

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.

Andrea Arighi (A)

Fondazione IRCSS ca' Granda, Ospedale Policlinico, Milan, Italy.

Emanuela Rotondo (E)

Fondazione IRCSS ca' Granda, Ospedale Policlinico, Milan, Italy.

Antonio Tanzilli (A)

Neuro-Oncology Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Andrea Pace (A)

Neuro-Oncology Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Federica Garramone (F)

IRCCS Synlab SDN of Naples, Naples, Italy.

Carlo Cavaliere (C)

IRCCS Synlab SDN of Naples, Naples, Italy.

Matteo Pardini (M)

IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Department of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy.

Cristiano Rizzetto (C)

IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Department of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy.

Sandro Sorbi (S)

IRCCS Fondazione Don Carlo Gnocchi, ONLUS, Milan, Italy.

Roberta Perri (R)

Laboratory of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.

Pietro Tiraboschi (P)

Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

Nicola Canessa (N)

IUSS Cognitive Neuroscience (ICON) Center, Scuola Universitaria Superiore IUSS, Palazzo del Broletto, Piazza Vittoria 15, 27100, Pavia, Italy.
Istituti Clinici Scientifici Maugeri IRCCS, Cognitive Neuroscience Laboratory of Pavia Institute, Pavia, Italy.

Maria Cotelli (M)

IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.

Raffaele Ferri (R)

Department of Neurology IC, Oasi Research Institute - IRCCS, Troina, Italy.

Sandra Weintraub (S)

Mesulam Center for Cognitive Neurology and Alzheimer's Disease and Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Department of Neurology, Northwestern University, Chicago, IL, USA.

Camillo Marra (C)

Neurology Unit, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.

Fabrizio Tagliavini (F)

Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

Eleonora Catricalà (E)

IRCCS Mondino Foundation, Pavia, Italy.
IUSS Cognitive Neuroscience (ICON) Center, Scuola Universitaria Superiore IUSS, Palazzo del Broletto, Piazza Vittoria 15, 27100, Pavia, Italy.

Stefano Francesco Cappa (SF)

IRCCS Mondino Foundation, Pavia, Italy. stefano.cappa@iusspavia.it.
IUSS Cognitive Neuroscience (ICON) Center, Scuola Universitaria Superiore IUSS, Palazzo del Broletto, Piazza Vittoria 15, 27100, Pavia, Italy. stefano.cappa@iusspavia.it.

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