Attenuated HIV-1 Nef But Not Vpu Function in a Cohort of Rwandan Long-Term Survivors.
CD4
HIV non-progressors
HLA
downregulation
immune evasion
pathogenesis
tetherin
viral accessory proteins
Journal
Frontiers in virology (Lausanne, Switzerland)
ISSN: 2673-818X
Titre abrégé: Front Virol
Pays: Switzerland
ID NLM: 9918334884106676
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
entrez:
19
8
2022
pubmed:
20
8
2022
medline:
20
8
2022
Statut:
ppublish
Résumé
HIV-1 accessory proteins Nef and Vpu enhance viral pathogenesis through partially overlapping immune evasion activities. Attenuated Nef or Vpu functions have been reported in individuals who display slower disease progression, but few studies have assessed the relative impact of these proteins in non-B HIV-1 subtypes or examined paired proteins from the same individuals. Here, we examined the sequence and function of matched Nef and Vpu clones isolated from 29 long-term survivors (LTS) from Rwanda living with HIV-1 subtype A and compared our results to those of 104 Nef and 62 Vpu clones isolated from individuals living with chronic untreated HIV-1 subtype A from the same geographic area.
Identifiants
pubmed: 35982753
doi: 10.3389/fviro.2022.917902
pmc: PMC9383652
mid: NIHMS1828549
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIMH NIH HHS
ID : R01 MH054907
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI164565
Pays : United States
Organisme : NIH HHS
ID : P51 OD011132
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI027763
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Déclaration de conflit d'intérêts
Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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