Osteogenesis imperfecta and rheumatoid arthritis: connective issues.
Disease burden
Fractures
Genetics
Osteogenesis imperfecta
Rheumatoid arthritis
Traumatisms
Journal
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
ISSN: 1433-2965
Titre abrégé: Osteoporos Int
Pays: England
ID NLM: 9100105
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
pubmed:
20
8
2022
medline:
12
10
2022
entrez:
19
8
2022
Statut:
ppublish
Résumé
The coexistence of osteogenesis imperfecta and inflammatory arthritis has been very rarely described. Nevertheless, systemic inflammation has been found in osteogenesis imperfecta. The COL1A1 mutations may affect collagen synthesis as well as post-translational modifications, extracellular matrix interactions, and receptor-mediated signaling. Major collagen binding ligands forming the interactome, such as cytokines, cell adhesion molecules, matrix metalloproteinases, proteoglycans, and other molecules, are autoimmunity targets involved in rheumatoid arthritis pathogenesis. Cross-talk between bone remodeling and inflammatory pathways involving osteoclasts is important in osteogenesis imperfecta and rheumatoid arthritis. In osteogenesis imperfecta, the structural abnormalities and repeated traumatism, including fractures, could activate locally the innate immunity and trigger arthritis, similar to post-traumatic arthritis. Currently, the therapy of osteogenesis imperfecta is a suboptimally met need. Understanding the complex putative pathogenic links between osteogenesis imperfecta and inflammatory arthritis could hopefully lead to new therapeutic targets. Raising awareness regarding a possible association between osteogenesis imperfecta and arthritis could help improve the quality of life in these patients.
Identifiants
pubmed: 35984463
doi: 10.1007/s00198-022-06530-8
pii: 10.1007/s00198-022-06530-8
doi:
Substances chimiques
Collagen Type I
0
Cytokines
0
Ligands
0
Proteoglycans
0
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
2237-2239Informations de copyright
© 2022. International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation.
Références
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