RSPO2 defines a distinct undifferentiated progenitor in the tendon/ligament and suppresses ectopic ossification.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
19 Aug 2022
19 Aug 2022
Historique:
entrez:
19
8
2022
pubmed:
20
8
2022
medline:
20
8
2022
Statut:
ppublish
Résumé
Ectopic endochondral ossification in the tendon/ligament is caused by repetitive mechanical overload or inflammation. Tendon stem/progenitor cells (TSPCs) contribute to tissue repair, and some express lubricin [proteoglycan 4 (PRG4)]. However, the mechanisms of ectopic ossification and association of TSPCs are not yet known. Here, we investigated the characteristics of Prg4-positive (
Identifiants
pubmed: 35984875
doi: 10.1126/sciadv.abn2138
pmc: PMC9390986
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabn2138Références
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