Update on Pediatric Hyperthyroidism.
Graves’ disease
Hyperthyroidism in children
Neonatal hyperthyroidism
Journal
Advances in pediatrics
ISSN: 1878-1926
Titre abrégé: Adv Pediatr
Pays: United States
ID NLM: 0370436
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
entrez:
19
8
2022
pubmed:
20
8
2022
medline:
24
8
2022
Statut:
ppublish
Résumé
Typical symptoms which should lead to suspicion of hyperthyroidism are unintentional weight loss, tachycardia, and palpitations, heat intolerance, and hyperactivity. It is diagnosed by suppressed thyroid-stimulating hormone (TSH) with elevated thyroid hormone (TH) levels. Graves' disease (GD) due to antibodies stimulating the TSH receptor is the leading cause, and first-line treatment is with methimazole (MMI). Emerging data suggest MMI treatment, up to 8 years is effective and safe in improving the rate of remission. Radioactive iodine (RAI) and thyroidectomy offer definitive treatment and induce permanent hypothyroidism. Thyroid storm is a life-threatening condition with systemic decompensation and hyperpyrexia. Neonates of mothers with current or past GD are at risk for neonatal hyperthyroidism (NH). Appropriate identification and follow-up of at-risk neonates will reduce complications.
Identifiants
pubmed: 35985711
pii: S0065-3101(22)00018-4
doi: 10.1016/j.yapd.2022.04.004
pii:
doi:
Substances chimiques
Iodine Radioisotopes
0
Methimazole
554Z48XN5E
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
219-229Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Disclosure The authors have nothing to disclose.