Insight into Isolation and Characterization of Phenolic Compounds from Hawthorn (Crataegus pinnatifida Bge.) with Antioxidant, Anti-Acetylcholinesterase, and Neuroprotective Activities.
Acetylcholinesterase inhibitors activity
Antioxidant activity
Functional food
Hawthorn
Neuroprotective activity
Journal
Plant foods for human nutrition (Dordrecht, Netherlands)
ISSN: 1573-9104
Titre abrégé: Plant Foods Hum Nutr
Pays: Netherlands
ID NLM: 8803554
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
accepted:
08
08
2022
pubmed:
20
8
2022
medline:
29
10
2022
entrez:
19
8
2022
Statut:
ppublish
Résumé
Recent epidemiologic studies have demonstrated a link between the consumption of daily functional fruits rich in phenols and the prevention of disease for neurodegenerative disorders. Hawthorn products are derived from the functional fruit hawthorn, which is rich in phenols and has been used around the world for centuries. In order to explore the phenolic components in hawthorn, the investigation of the ethanol extract led to the separation of five new phenol compounds (1a/1b, 2-4), including one pair of enantiomers (1a/1b), along with seven disclosed analogs (5-11). Their structures were elucidated based on extensive spectroscopic analyses and electronic circular dichroism (ECD). The compounds (1-11) were tested for antioxidant activities by 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonicacid) (ABTS), and ferric reducing antioxidant power (FRAP) methods. Apart from that, monomeric compounds 2, 4, and 6 exhibited more potent protective capabilities against H
Identifiants
pubmed: 35986175
doi: 10.1007/s11130-022-01004-y
pii: 10.1007/s11130-022-01004-y
doi:
Substances chimiques
Antioxidants
0
Hydrogen Peroxide
BBX060AN9V
Acetylcholinesterase
EC 3.1.1.7
Donepezil
8SSC91326P
Phenol
339NCG44TV
Plant Extracts
0
Phenols
0
Ethanol
3K9958V90M
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
538-544Subventions
Organisme : Science and Technology Planning Project of Liaoning Province
ID : 2021JH1/10400049
Organisme : Liaoning Revitalization Talents Program
ID : XLYC2007180
Organisme : Program for Major Scientific and Medical Technology Problems of China Medicine Education Association in 2020
ID : 2020KTS003
Organisme : Career Development Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University
ID : ZQN2018006
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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