Abnormal Uterine Bleeding Among COVID-19 Vaccinated and Recovered Women: a National Survey.
Abnormal uterine bleeding
BNT162b2 vaccine
COVID-19
Menstrual changes
Pfizer vaccine
Journal
Reproductive sciences (Thousand Oaks, Calif.)
ISSN: 1933-7205
Titre abrégé: Reprod Sci
Pays: United States
ID NLM: 101291249
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
received:
24
03
2022
accepted:
04
08
2022
pubmed:
20
8
2022
medline:
9
3
2023
entrez:
19
8
2022
Statut:
ppublish
Résumé
The objective of this research was to characterize menstrual changes including amount, duration, and frequency among COVID-19 vaccinated and infected women. We conducted an online nationwide questionnaire survey on premenopausal, non-pregnant women over 18 years of age in Israel, querying about any changes in their menstrual patterns after COVID-19 vaccination or infection. In total, 10,319 women responded, of which 7904 met the inclusion criteria. Changes in menstrual patterns following COVID-19 vaccination or infection were reported in 3689/7476 (49.3%) women compared with 202/428 (47.2%) women, respectively, (P = .387). The most commonly described menstrual disturbance was excessive bleeding (heavy, prolonged, or intermenstrual) in both the vaccinated and infected groups, (80.6% versus 81.4%, respectively, P = .720). Among women who experienced abnormal uterine bleeding (AUB), in most cases (61.1%), it occurred between the vaccination and the ensuing menstrual period. Menstrual disturbances were similar in type among the vaccinated and infected women. In conclusion, AUB emerged as a side effect of the BNT162b2 vaccine and a symptom of the COVID-19 infection and was characterized mainly by excessive bleeding. Although the precise incidence could not be determined in this study, the type of bleeding disorder as well as the characterization of risk factors including increasing age and a baseline menstrual pattern of prolonged, frequent, and heavy menses are well defined. The incidence and the long-term consequences of the BNT162b2 vaccine on uterine bleeding warrant further investigation.
Identifiants
pubmed: 35986194
doi: 10.1007/s43032-022-01062-2
pii: 10.1007/s43032-022-01062-2
pmc: PMC9390105
doi:
Substances chimiques
BNT162 Vaccine
0
COVID-19 Vaccines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
713-721Informations de copyright
© 2022. The Author(s), under exclusive licence to Society for Reproductive Investigation.
Références
Vaccine EUAEotP-BC-. Emergency use authorization (EUA) of the Pfizer-BioNTech COVID-19 vaccine to prevent Coronavirus. Fact sheet for healthcare providers administering vaccine. Available from: https://www.fda.gov/media/144413/download .
Oliver SE, Gargano JW, Marin M, Wallace M, Curran KG, Chamberland M, et al. The Advisory Committee on Immunization Practices’ Interim Recommendation for use of Pfizer-BioNTech COVID-19 vaccine - United States, December 2020. MMWR Morb Mortal Wkly Rep. 2020;69(50):1922–4.
doi: 10.15585/mmwr.mm6950e2
pubmed: 33332292
pmcid: 7745957
Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med. 2020;383(27):2603–15.
doi: 10.1056/NEJMoa2034577
pubmed: 33301246
Li K, Chen G, Hou H, Liao Q, Chen J, Bai H, et al. Analysis of sex hormones and menstruation in COVID-19 women of child-bearing age. Reprod Biomed Online. 2021;42(1):260–7.
doi: 10.1016/j.rbmo.2020.09.020
pubmed: 33288478
Munro MG, Critchley HOD, Fraser IS. The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions. Int J Gynaecol Obstet. 2018;143(3):393–408.
doi: 10.1002/ijgo.12666
pubmed: 30198563
Practice bulletin no. 128: diagnosis of abnormal uterine bleeding in reproductive-aged women. Obstet Gynecol. 2012;120(1):197–206.
doi: 10.1097/AOG.0b013e318262e320
Harlow SD, Campbell OM. Epidemiology of menstrual disorders in developing countries: a systematic review. BJOG. 2004;111(1):6–16.
doi: 10.1111/j.1471-0528.2004.00012.x
pubmed: 14687045
Kazemijaliseh H, Ramezani Tehrani F, Behboudi-Gandevani S, Khalili D, Hosseinpanah F, Azizi F. A population-based study of the prevalence of abnormal uterine bleeding and its related factors among Iranian reproductive-age women: an updated data. Arch Iran Med. 2017;20(9):558–63.
pubmed: 29048917
Liu Z, Doan QV, Blumenthal P, Dubois RW. A systematic review evaluating health-related quality of life, work impairment, and health-care costs and utilization in abnormal uterine bleeding. Value Health. 2007;10(3):183–94.
doi: 10.1111/j.1524-4733.2007.00168.x
pubmed: 17532811
Israeli ministry of health website Israeli ministry of health website [Available from: https://datadashboard.health.gov.il/COVID-19/general .
Nguyen BT, Pang RD, Nelson AL, Pearson JT, Benhar Noccioli E, Reissner HR, et al. Detecting variations in ovulation and menstruation during the COVID-19 pandemic, using real-world mobile app data. PLoS One. 2021;16(10): e0258314.
doi: 10.1371/journal.pone.0258314
pubmed: 34669726
pmcid: 8528316
Buran G, Gerçek ÖE. Impact of the awareness and fear of COVID-19 on menstrual symptoms in women: a cross-sectional study. Health Care Women Int. 2022;43(4):413–27.
doi: 10.1080/07399332.2021.2004149
pubmed: 34843413
Edelman A, Boniface ER, Benhar E, Han L, Matteson KA, Favaro C, et al. Association between menstrual cycle length and Coronavirus Disease 2019 (COVID-19) Vaccination: A U.S. Cohort. Obstet Gynecol. 2022.
Trogstad L. Increased occurrence of menstrual disturbances in 18-to 30-year-old women after Covid-19 vaccination. Available at SSRN 3998180. 2022.
Phelan N, Behan LA, Owens L. The Impact of the COVID-19 pandemic on women’s reproductive health. Front Endocrinol (Lausanne). 2021;12: 642755.
doi: 10.3389/fendo.2021.642755
pubmed: 33841334
Alghamdi AN, Alotaibi MI, Alqahtani AS, Al Aboud D, Abdel-Moneim AS. BNT162b2 and ChAdOx1 SARS-CoV-2 Post-vaccination side-effects among Saudi vaccinees. Front Med (Lausanne). 2021;8: 760047.
doi: 10.3389/fmed.2021.760047
pubmed: 34692740
Male V. Menstruation and Covid-19 vaccination. BMJ. 2022;376: o142.
doi: 10.1136/bmj.o142
pubmed: 35082132
Medicines and Healthcare Products Regulatory Agency. Coronavirus vaccine—weekly summary of yellow card reporting. 2022. [Available from: https://www.gov.uk/government/publications/coronavirus-covid-19-vaccine-adverse-reactions/coronavirus-vaccine-summary-of-yellow-card-reporting#annex-1-vaccine-analysis-print .
Eunice Kennedy Shriver National Institute of Child Health and Human Development. Item of interest: NIH funds studies to assess potential effects of COVID-19 vaccination on menstruation. 2021. [Available from: https://www.nichd.nih.gov/newsroom/news/083021-COVID-19-vaccination-menstruation .
Laganà AS, Veronesi G, Ghezzi F, Ferrario MM, Cromi A, Bizzarri M, et al. Evaluation of menstrual irregularities after COVID-19 vaccination: results of the MECOVAC survey. Open Med (Wars). 2022;17(1):475–84.
doi: 10.1515/med-2022-0452
pubmed: 35350834
Demir O, Sal H, Comba C. Triangle of COVID, anxiety and menstrual cycle. J Obstet Gynaecol. 2021;41(8):1257–61.
doi: 10.1080/01443615.2021.1907562
pubmed: 33955327
Kurmanova AM, Kurmanova GM, Lokshin VN. Reproductive dysfunctions in viral hepatitis. Gynecol Endocrinol. 2016;32(sup2):37–40.
doi: 10.1080/09513590.2016.1232780
pubmed: 27759450
Karagiannis A, Harsoulis F. Gonadal dysfunction in systemic diseases. Eur J Endocrinol. 2005;152(4):501–13.
doi: 10.1530/eje.1.01886
pubmed: 15817904
Katsoularis I, Fonseca-Rodríguez O, Farrington P, Jerndal H, Lundevaller EH, Sund M, et al. Risks of deep vein thrombosis, pulmonary embolism, and bleeding after Covid-19: nationwide self-controlled cases series and matched cohort study. BMJ. 2022;377: e069590.
doi: 10.1136/bmj-2021-069590
pubmed: 35387772
Lee EJ, Cines DB, Gernsheimer T, Kessler C, Michel M, Tarantino MD, et al. Thrombocytopenia following Pfizer and Moderna SARS-CoV-2 vaccination. Am J Hematol. 2021;96(5):534–7.
doi: 10.1002/ajh.26132
pubmed: 33606296
pmcid: 8014568
Grobler C, Maphumulo SC, Grobbelaar LM, Bredenkamp JC, Laubscher GJ, Lourens PJ, et al. Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and their Interactions with endothelial cells, platelets and erythrocytes. Int J Mol Sci. 2020;21(14).
Carli G, Nichele I, Ruggeri M, Barra S, Tosetto A. Deep vein thrombosis (DVT) occurring shortly after the second dose of mRNA SARS-CoV-2 vaccine. Intern Emerg Med. 2021;16(3):803–4.
doi: 10.1007/s11739-021-02685-0
pubmed: 33687691
pmcid: 7940863
Tajstra M, Jaroszewicz J, Gąsior M. Acute Coronary Tree Thrombosis After Vaccination for COVID-19. JACC Cardiovasc Interv. 2021;14(9):e103–4.
doi: 10.1016/j.jcin.2021.03.003
pubmed: 33958175
pmcid: 8092130
Suzuki S, Hosono A. No association between HPV vaccine and reported post-vaccination symptoms in Japanese young women: Results of the Nagoya study. Papillomavirus Res. 2018;5:96–103.
doi: 10.1016/j.pvr.2018.02.002
pubmed: 29481964
pmcid: 5887012
Wei S, Schmidt MD, Dwyer T, Norman RJ, Venn AJ. Obesity and menstrual irregularity: associations with SHBG, testosterone, and insulin. Obesity (Silver Spring). 2009;17(5):1070–6.
doi: 10.1038/oby.2008.641
pubmed: 19180069
Mena GP, Mielke GI, Brown WJ. Prospective associations between physical activity and BMI with irregular periods and heavy menstrual bleeding in a large cohort of Australian women. Hum Reprod. 2021;36(6):1481–91.
doi: 10.1093/humrep/deab055
pubmed: 33846724
Broughton DE, Moley KH. Obesity and female infertility: potential mediators of obesity’s impact. Fertil Steril. 2017;107(4):840–7.
doi: 10.1016/j.fertnstert.2017.01.017
pubmed: 28292619
Villavicencio J, Allen RH. Unscheduled bleeding and contraceptive choice: increasing satisfaction and continuation rates. Open Access J Contracept. 2016;7:43–52.
pubmed: 29386936
pmcid: 5683158
Lethaby A, Wise MR, Weterings MA, Bofill Rodriguez M, Brown J. Combined hormonal contraceptives for heavy menstrual bleeding. Cochrane Database Syst Rev. 2019;2(2):Cd000154.
pubmed: 30742315
Male V. Menstrual changes after Covid-19 vaccination. BMJ. 2021;374: n2211.
doi: 10.1136/bmj.n2211
pubmed: 34526310