Dual-action of colloidal ISCOMs: an optimized approach using Box-Behnken design for the management of breast cancer.
Apoptosis
Box-Behnken design
Breast cancer
Immune stimulating complexes
MCF-7 cell line
Neuropeptide Y
Journal
Biomedical microdevices
ISSN: 1572-8781
Titre abrégé: Biomed Microdevices
Pays: United States
ID NLM: 100887374
Informations de publication
Date de publication:
20 08 2022
20 08 2022
Historique:
accepted:
16
06
2022
entrez:
20
8
2022
pubmed:
21
8
2022
medline:
24
8
2022
Statut:
epublish
Résumé
Neuropeptide Y (NPY) occurs in G-protein-coupled receptors and offers targeted effects at the active sites for therapeutic action in various conditions like depression, stress, obesity and cancer. Immune stimulating complexes (ISCOMs) associate peptides with the lipid systems for enhancing antigen targeting to provide site-specific action and B-cell response. The present study focused on the encapsulation of NPY in ISCOMs to comprise dual action in the form of immunity modulation and management of breast cancer by arresting G0/G1 phase. The colloidal ISCOMs were prepared by coupling method and further optimized by Box-Behnken design of Design of Experiment (DoE) software. The NPY-loaded ISCOMs (formulation ISCN) were characterized by various parameters with higher % encapsulation efficiency of 87.99 ± 1.87% and in-vitro release of 84.16±3.2% of NPY for 24 h. The study of MTT assay on MCF-7 cell line for formulation ISCN exhibited a significant decrease in the cell growth of 66.41±4.7% at 10 µg/mL compared to plain NPY (52.21±0.04%). The MCF-7 cells showed a significant reduction in cytokine levels in the presence of formulation ISCN wherein T
Identifiants
pubmed: 35986783
doi: 10.1007/s10544-022-00625-z
pii: 10.1007/s10544-022-00625-z
doi:
Substances chimiques
Antigen-Antibody Complex
0
Cytokines
0
ISCOMs
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
28Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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