Fluorene-9-bisphenol regulates steroidogenic hormone synthesis in H295R cells through the AC/cAMP/PKA signaling pathway.
BHPF
Endocrine disruption
In vitro
Signal transduction
Steroidogenesis
Journal
Ecotoxicology and environmental safety
ISSN: 1090-2414
Titre abrégé: Ecotoxicol Environ Saf
Pays: Netherlands
ID NLM: 7805381
Informations de publication
Date de publication:
15 Sep 2022
15 Sep 2022
Historique:
received:
17
05
2022
revised:
11
08
2022
accepted:
13
08
2022
pubmed:
21
8
2022
medline:
9
9
2022
entrez:
20
8
2022
Statut:
ppublish
Résumé
Fluorene-9-bisphenol (BHPF), which has been used as a substitute for bisphenol A (BPA) in consumer goods and industrial products, can be detected in environmental media and human urine. BHPF has been reported to have endocrine-disrupting effects, whereas deleterious effects on steroidogenesis in H295R cells and underlying mechanisms are still unclear. Here, we investigated effects of BHPF on steroidogenesis using human adrenocortical carcinoma cells (H295R). Cytotoxicity was initially assessed and half-maximal inhibitory concentration (IC
Identifiants
pubmed: 35987080
pii: S0147-6513(22)00822-3
doi: 10.1016/j.ecoenv.2022.113982
pii:
doi:
Substances chimiques
Benzhydryl Compounds
0
Fluorenes
0
Phenols
0
fluorene-9-bisphenol
0
Testosterone
3XMK78S47O
Aldosterone
4964P6T9RB
Bucladesine
63X7MBT2LQ
Steroid 11-beta-Hydroxylase
EC 1.14.15.4
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113982Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.