Gene-diet interactions and cardiovascular diseases: a systematic review of observational and clinical trials.

Cardiovascular Diseases / diagnosis Cross-Sectional Studies Diet / adverse effects Humans Myocardial Infarction / epidemiology Prospective Studies
Cardiovascular diseases Coronary heart disease Diet Gene-diet interaction Myocardial infarction Stroke

Journal

BMC cardiovascular disorders
ISSN: 1471-2261
Titre abrégé: BMC Cardiovasc Disord
Pays: England
ID NLM: 100968539

Informations de publication

Date de publication:
20 08 2022
Historique:
received: 15 02 2022
accepted: 28 07 2022
entrez: 20 8 2022
pubmed: 21 8 2022
medline: 24 8 2022
Statut: epublish

Résumé

Both genetic background and diet are important determinants of cardiovascular diseases (CVD). Understanding gene-diet interactions could help improve CVD prevention and prognosis. We aimed to summarise the evidence on gene-diet interactions and CVD outcomes systematically. We searched MEDLINE We included 59 articles based on data from 29 studies; six articles involved multiple studies, and seven did not report details of their source population. The median sample size of the articles was 2562 participants. Of the 59 articles, 21 (35.6%) were qualified as high quality, while the rest were intermediate or poor. Eleven (18.6%) articles adjusted for multiple comparisons, four (7.0%) attempted to replicate the findings, 18 (30.5%) were based on Han-Chinese ethnicity, and 29 (49.2%) did not present Minor Allele Frequency. Fifty different dietary exposures and 52 different genetic factors were investigated, with alcohol intake and ADH1C variants being the most examined. Of 266 investigated diet-gene interaction tests, 50 (18.8%) were statistically significant, including CETP-TaqIB and ADH1C variants, which interacted with alcohol intake on CHD risk. However, interactions effects were significant only in some articles and did not agree on the direction of effects. Moreover, most of the studies that reported significant interactions lacked replication. Overall, the evidence on gene-diet interactions on CVD is limited, and lack correction for multiple testing, replication and sample size consideration.

Sections du résumé

BACKGROUND
Both genetic background and diet are important determinants of cardiovascular diseases (CVD). Understanding gene-diet interactions could help improve CVD prevention and prognosis. We aimed to summarise the evidence on gene-diet interactions and CVD outcomes systematically.
METHODS
We searched MEDLINE
RESULTS AND DISCUSSION
We included 59 articles based on data from 29 studies; six articles involved multiple studies, and seven did not report details of their source population. The median sample size of the articles was 2562 participants. Of the 59 articles, 21 (35.6%) were qualified as high quality, while the rest were intermediate or poor. Eleven (18.6%) articles adjusted for multiple comparisons, four (7.0%) attempted to replicate the findings, 18 (30.5%) were based on Han-Chinese ethnicity, and 29 (49.2%) did not present Minor Allele Frequency. Fifty different dietary exposures and 52 different genetic factors were investigated, with alcohol intake and ADH1C variants being the most examined. Of 266 investigated diet-gene interaction tests, 50 (18.8%) were statistically significant, including CETP-TaqIB and ADH1C variants, which interacted with alcohol intake on CHD risk. However, interactions effects were significant only in some articles and did not agree on the direction of effects. Moreover, most of the studies that reported significant interactions lacked replication. Overall, the evidence on gene-diet interactions on CVD is limited, and lack correction for multiple testing, replication and sample size consideration.

Identifiants

DOI: 10.1186/s12872-022-02808-1 PMID: 35987633 PMC: PMC9392936
pubmed: 35987633
doi: 10.1186/s12872-022-02808-1
pii: 10.1186/s12872-022-02808-1
pmc: PMC9392936
doi:

Types de publication

Journal Article Systematic Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

377

Subventions

Organisme : Medical Research Council
ID : MR/S019669/1
Pays : United Kingdom

Informations de copyright

© 2022. The Author(s).

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Auteurs

Zayne M Roa-Díaz (ZM)

Institute of Social and Preventive Medicine (ISPM), University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland. zayne.roadiaz@ispm.unibe.ch.
Graduate School for Health Sciences, University of Bern, Bern, Switzerland. zayne.roadiaz@ispm.unibe.ch.

Julian Teuscher (J)

Institute of Social and Preventive Medicine (ISPM), University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland.

Magda Gamba (M)

Institute of Social and Preventive Medicine (ISPM), University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland.
Graduate School for Health Sciences, University of Bern, Bern, Switzerland.

Marvin Bundo (M)

Institute of Social and Preventive Medicine (ISPM), University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland.
Graduate School for Health Sciences, University of Bern, Bern, Switzerland.
Oeschger Center for Climate Change Research, University of Bern, Bern, Switzerland.

Giorgia Grisotto (G)

Institute of Social and Preventive Medicine (ISPM), University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland.
Graduate School for Health Sciences, University of Bern, Bern, Switzerland.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Faina Wehrli (F)

Institute of Social and Preventive Medicine (ISPM), University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland.

Edna Gamboa (E)

School of Nutrition and Dietetics, Health Faculty, Universidad Industrial de Santander, Bucaramanga, Colombia.

Lyda Z Rojas (LZ)

Nursing Research and Knowledge Development Group GIDCEN, Fundación Cardiovascular de Colombia, Floridablanca, Colombia.

Sergio A Gómez-Ochoa (SA)

Institute of Social and Preventive Medicine (ISPM), University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland.

Sanne Verhoog (S)

Institute of Social and Preventive Medicine (ISPM), University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland.
Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Manuel Frias Vargas (MF)

Centro de Salud Universitario Comillas, Madrid, Spain.

Beatrice Minder (B)

Public Health & Primary Care Library, University Library of Bern, University of Bern, Bern, Switzerland.

Oscar H Franco (OH)

Institute of Social and Preventive Medicine (ISPM), University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland.

Abbas Dehghan (A)

Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UK.

Raha Pazoki (R)

Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UK.
Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
CIRTM Centre for Inflammation Research and Translational Medicine, College of Health and Life Sciences, Brunel University London, Uxbridge, UK.

Pedro Marques-Vidal (P)

Department of Medicine, Internal Medicine, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.

Taulant Muka (T)

Institute of Social and Preventive Medicine (ISPM), University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland.

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Classifications MeSH

questionsmedicales.fr › Maladies cardiovasculaires › Gene-diet interactions and cardiovascular...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Gene-diet interactions and cardiovascular...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Gene-diet interactions and cardiovascular...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Gene-diet interactions and cardiovascular...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus du myocarde › Gene-diet interactions and cardiovascular...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Gene-diet interactions and cardiovascular...