Specificity of viscumin revised. As probed with a printed glycan array.

Animals Lactose Mammals Polysaccharides Ribosome Inactivating Proteins, Type 2 Sulfates
Printed glycan array Sialoglycan Sulfated glycan Viscumin αGal epitope

Journal

Biochimie
ISSN: 1638-6183
Titre abrégé: Biochimie
Pays: France
ID NLM: 1264604

Informations de publication

Date de publication:
Nov 2022
Historique:
received: 06 07 2022
revised: 11 08 2022
accepted: 13 08 2022
pubmed: 22 8 2022
medline: 23 11 2022
entrez: 21 8 2022
Statut: ppublish

Résumé

Viscumin, a lectin used in anti-cancer therapy, was originally considered as βGal recognizing protein; later, an ability to bind 6'-sialyl N-acetyllactosamine (6'SLN) terminated gangliosides was found. Here we probed viscumin with a printed glycan array (PGA) containing a large number of mammalian sulfated glycans, and found a strong binding to glycans with 6-O-SuGal moiety as lactose, N-acetyllactosamine (LN), di-N-acetyllactosamine (LacdiNAc), and even 6-O-SuGalNAcα (but not SiaTn). Also, the ability to bind some of αGal terminated glycans, including Galα1-3Galβ1-4GlcNAc, was observed. Unexpectedly, only weak interaction was detected with parent neutral β-galactosides including LN-LN-LN and branched (LN)

Identifiants

DOI: 10.1016/j.biochi.2022.08.009 PMID: 35988841
pubmed: 35988841
pii: S0300-9084(22)00213-9
doi: 10.1016/j.biochi.2022.08.009
pii:
doi:

Substances chimiques

Lactose J2B2A4N98G
mistletoe lectin I 0
Polysaccharides 0
Ribosome Inactivating Proteins, Type 2 0
Sulfates 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

94-102

Informations de copyright

Copyright © 2022 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Nadezhda Shilova (N)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia; National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation, 4 Oparina str., Moscow, 117997, Russia.

Nicolai Bovin (N)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia; Auckland University of Technology, School of Engineering, Computer and Mathematical Sciences, Auckland, New Zealand.

Diana Maltseva (D)

Faculty of Biology and Biotechnology, HSE University, 33 b.4 Profsoyuznaya str., Moscow, 117418, Russia. Electronic address: d.maltseva@hse.ru.

Svetlana Polyakova (S)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia.

Marina Sablina (M)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia.

Hideaki Niwa (H)

RIKEN Center for Biosystems Dynamics Research (BDR), 1-7-22 Suehiro-cho, Tsurumi, Yokohama, 230-0045, Japan.

Galina Zakharova (G)

Scientific Research Center Bioclinicum, 2/85 Ugreshkaya str., Moscow, 115088, Russia.

Maria Raygorodskaya (M)

Faculty of Biology and Biotechnology, HSE University, 33 b.4 Profsoyuznaya str., Moscow, 117418, Russia; Research Institute of Urology and Interventional Radiology Named After N.A. Lopatkin of the Ministry of Healthcare of Russian Federation, 51-1 3-ya Parkovaya str., Moscow, 105425, Russia.

Lyuba Bufeeva (L)

Faculty of Biology and Biotechnology, HSE University, 33 b.4 Profsoyuznaya str., Moscow, 117418, Russia.

Yury Belyi (Y)

N.F. Gamaleya Research Centre of Epidemiology and Microbiology, 18 Gamaleya str., Moscow, 123098, Russia.

Dmitry Hushpulian (D)

School of Biomedicine, Far Eastern Federal University, Vladivostok, 690091, Russia.

Alexander Tonevitsky (A)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia; Faculty of Biology and Biotechnology, HSE University, 33 b.4 Profsoyuznaya str., Moscow, 117418, Russia.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Specificity of viscumin revised. As probed...
questionsmedicales.fr › Glucides › Sucres › Diholoside › Lactose › Specificity of viscumin revised. As probed...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Specificity of viscumin revised. As probed...
questionsmedicales.fr › Glucides › Polyosides › Specificity of viscumin revised. As probed...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines végétales › Protéines inactivant les ribosomes › Protéines inactivant les ribosomes de type 2 › Specificity of viscumin revised. As probed...
questionsmedicales.fr › Produits chimiques inorganiques › Sulfates › Specificity of viscumin revised. As probed...