Enhancement of nerve regeneration with nimodipine treatment after sciatic nerve injury.
crush
nimodipine
regeneration
sciatic nerve
Journal
Fundamental & clinical pharmacology
ISSN: 1472-8206
Titre abrégé: Fundam Clin Pharmacol
Pays: England
ID NLM: 8710411
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
revised:
02
08
2022
received:
09
05
2022
accepted:
18
08
2022
pubmed:
23
8
2022
medline:
25
1
2023
entrez:
22
8
2022
Statut:
ppublish
Résumé
Peripheral nerve injuries (PNI/s) are common orthopedic conditions, characterized by motor and sensory deficits in the damaged region. There is growing evidence that the L-type calcium channel antagonist nimodipine has neuroprotective and neuroregenerative effects in animal models of neurological disorders. The efficacy of nimodipine on improving motor function and sensation following a sciatic nerve crush model was investigated in male Wistar rats as a model of PNI. At different time periods following damage, we evaluated motor function, sensory recovery, electrophysiology, histomorphometry, and gene expression. Moreover, we used histological and mass ratio analysis of the gastrocnemius muscle to assess atrophy. Our findings suggest that the nimodipine improves motor and sensory function more quickly in the damaged region 2, 4, and 6 weeks after 1 week of treatment. Nimodipine treatment also increased the number of myelinated fibers while decreasing their thickness, as shown by histomorphometry. Additionally, nimodipine treatment increases the mRNA levels of neurotrophic factors (BDNF and NGF), which are known to contribute to the regeneration of injured neurons. The impact of nimodipine in PNI recovery may be due to its stimulation of the CREB signaling pathway and suppression of pro-inflammatory factor production.
Substances chimiques
Nimodipine
57WA9QZ5WH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
107-115Subventions
Organisme : University of Mohaghegh Ardabili
Informations de copyright
© 2022 Société Française de Pharmacologie et de Thérapeutique. Published by John Wiley & Sons Ltd.
Références
Abdolmaleki A, Zahri S, Bayrami A. Rosuvastatin enhanced functional recovery after sciatic nerve injury in the rat. Eur J Pharmacol. 2020;173260. doi:10.1016/j.ejphar.2020.173260
Soluki M, Mahmoudi F, Abdolmaleki A, Asadi A, Namini AS. Cerium oxide nanoparticles as a new neuroprotective agent to promote functional recovery in a rat model of sciatic nerve crush injury. Br J Neurosurg. 2020;1-6. doi:10.1080/02688697.2020.1864292
Zhu L, Jia S, Liu T, et al. Aligned PCL fiber conduits immobilized with nerve growth factor gradients enhance and direct sciatic nerve regeneration. Adv Funct Mater. 2020;30(39):2002610. doi:10.1002/adfm.202002610
Ghayour MB, Abdolmaleki A, Rassouli MB. Neuroprotective effect of lovastatin on motor deficit induced by sciatic nerve crush in the rat. Eur J Pharmacol. 2017;812:121-127. doi:10.1016/j.ejphar.2017.07.018
Asadi A, Zahri S, Abdolmaleki A. Biosynthesis, characterization and evaluation of the supportive properties and biocompatibility of DBM nanoparticles on a tissue-engineered nerve conduit from decellularized sciatic nerve. Regenerative Therapy. 2020;14:315-321. doi:10.1016/j.reth.2020.03.004
Ghayour MB, Abdolmaleki A, Behnam-Rassouli M. The effect of Riluzole on functional recovery of locomotion in the rat sciatic nerve crush model. Eur J Trauma Emerg Surg. 2017;43(5):691-699. doi:10.1007/s00068-016-0691-4
Abbaszadeh S, Asadi A, Zahri S, Abdolmaleki A, Mahmoudi F. Does phenytoin have neuroprotective role and affect biocompatibility of decellularized sciatic nerve scaffold? Gene, Cell Tissue. 2020;8(1): doi:10.5812/gct.108726
Yaksh TL. Calcium channels as therapeutic targets in neuropathic pain. J Pain. 2006;7(1):S13-S30. doi:10.1016/j.jpain.2005.09.007
Ghayour M-B, Abdolmaleki A, Behnam-Rassouli M. The effect of memantine on functional recovery of the sciatic nerve crush injury in rats. Turk Neurosurg. 2017;27(4):641-647. doi:10.5137/1019-5149.JTN.16792-15.1
Ahad MA, Kumaran KR, Ning T, et al. Insights into the neuropathology of cerebral ischemia and its mechanisms. Rev Neurosci. 2020;1(5):521-538. doi:10.1515/revneuro-2019-0099
Nakanishi N, Tu S, Shin Y, et al. Neuroprotection by the NR3A subunit of the NMDA receptor. J Neurosci. 2009;29(16):5260-5265. doi:10.1523/JNEUROSCI.1067-09.2009
Marcantoni M, Fuchs A, Löw P, Kiehn O, Bellardita C. Nimodipine prevents the development of spasticity after spinal cord injury. bioRxiv. 2019;639211.
Mattsson P, Janson AM, Aldskogius H, Svensson M. Nimodipine promotes regeneration and functional recovery after intracranial facial nerve crush. J Comp Neurol. 2001;437(1):106-117. doi:10.1002/cne.1273
Hopp SC. Targeting microglia L-type voltage-dependent calcium channels for the treatment of central nervous system disorders. J Neurosci Res. 2021;99(1):141-162. doi:10.1002/jnr.24585
Heck A, Fastenrath M, Coynel D, et al. Genetic analysis of association between calcium signaling and hippocampal activation, memory performance in the young and old, and risk for sporadic Alzheimer disease. JAMA Psychiat. 2015;72(10):1029-1036. doi:10.1001/jamapsychiatry.2015.1309
Schampel A, Volovitch O, Koeniger T, et al. Nimodipine fosters remyelination in a mouse model of multiple sclerosis and induces microglia-specific apoptosis. Proc Natl Acad Sci. 2017;114(16):E3295-E3304. doi:10.1073/pnas.1620052114
Ingwersen J, de Santi L, Wingerath B, et al. Nimodipine confers clinical improvement in two models of experimental autoimmune encephalomyelitis. J Neurochem. 2018;146(1):86-98. doi:10.1111/jnc.14324
Roe MS, Wahab B, Török Z, Horváth I, Vigh L, Prodromou C. Dihydropyridines allosterically modulate Hsp90 providing a novel mechanism for heat shock protein co-induction and neuroprotection. Front Mol Biosci. 2018;5:51. doi:10.3389/fmolb.2018.00051
Paris D, Ait-Ghezala G, Bachmeier C, et al. The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation. J Biol Chem. 2014;289(49):33927-33944. doi:10.1074/jbc.M114.608091
Li Y, Hu X, Liu Y, Bao Y, An L. Nimodipine protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation. Neuropharmacology. 2009;56(3):580-589. doi:10.1016/j.neuropharm.2008.10.016
Ma B, Zhang J. Nimodipine treatment to assess a modified mouse model of intracerebral hemorrhage. Brain Res. 2006;1078(1):182-188. doi:10.1016/j.brainres.2006.01.045
Jia Y, Gao H, Ma L, Li J. Effect of nimodipine on rat spinal cord injury. Genet Mol Res. 2015;14(1):1269-1276. doi:10.4238/2015.February.13.5
Bain J, Mackinnon S, Hunter D. Functional evaluation of complete sciatic, peroneal, and posterior tibial nerve lesions in the rat. Plast Reconstr Surg. 1989;83(1):129-138. doi:10.1097/00006534-198901000-00024
Mohammad-Bagher G, Arash A, Morteza B-R, Naser M-S, Ali M. Synergistic effects of acetyl-l-carnitine and adipose-derived stromal cells on improving regenerative capacity of acellular nerve allograft in sciatic nerve defect. Journal of Pharmacology and Experimental Therapeutics. 2019;368(3):490-502. doi:10.1124/jpet.118.254540
Gholami A, Asadi A, Abdolmaleki A, Zahri S. Evaluating the efficiency of selenium nanoparticles in the production of decellularized neural scaffold and the ability to preserve stem cells cultured on them: a laboratory study. J Rafsanjan Univ Med Sci. 2021;20(7):733-746. doi:10.52547/jrums.20.7.733
Chen M-M, Qin J, Chen S-J, et al. Quercetin promotes motor and sensory function recovery following sciatic nerve-crush injury in C57BL/6J mice. J Nutr Biochem. 2017;46:57-67. doi:10.1016/j.jnutbio.2017.04.006
Mattsson P, Frostell A, Björck G, et al. Recovery of voice after reconstruction of the recurrent laryngeal nerve and adjuvant nimodipine. World J Surg. 2018;42(3):632-638. doi:10.1007/s00268-017-4235-9
Zheng X-s, Ying T-t, Yuan Y, Li S-t. Nimodipine-mediated re-myelination after facial nerve crush injury in rats. J Clin Neurosci. 2015;22(10):1661-1668. doi:10.1016/j.jocn.2015.03.048
Bota O, Fodor L. The influence of drugs on peripheral nerve regeneration. Drug Metab Rev. 2019;51(3):266-292. doi:10.1080/03602532.2019.1632885
Lin RJ, Klein-Fedyshin M, Rosen CA. Nimodipine improves vocal fold and facial motion recovery after injury: a systematic review and meta-analysis. Laryngoscope. 2019;129(4):943-951. doi:10.1002/lary.27530
Guntinas-Lichius O, Martinez-Portillo F, Lebek J, Angelov D, Stennert E, Neiss W. Nimodipine maintains in vivo the increase in GFAP and enhances the astroglial ensheathment of surviving motoneurons in the rat following permanent target deprivation. J Neurocytol. 1997;26(4):241-248. doi:10.1023/A:1018592215557
Rong Y, Liu W, Lv C, et al. Neural stem cell small extracellular vesicle-based delivery of 14-3-3t reduces apoptosis and neuroinflammation following traumatic spinal cord injury by enhancing autophagy by targeting Beclin-1. Aging (Albany NY). 2019;11(18):7723-7745. doi:10.18632/aging.102283
Block ML, Hong J-S. Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol. 2005;76(2):77-98. doi:10.1016/j.pneurobio.2005.06.004
Poblete RA, Arenas M, Sanossian N, Freeman WD, Louie SG. The role of bioactive lipids in attenuating the neuroinflammatory cascade in traumatic brain injury. Annals of Clinical and Translational Neurology. 2020;7(12):2524-2534. doi:10.1002/acn3.51240
Hopp SC, Royer SE, D'angelo HM, Kaercher RM, Fisher DA, Wenk GL. Differential neuroprotective and anti-inflammatory effects of L-type voltage dependent calcium channel and ryanodine receptor antagonists in the substantia nigra and locus coeruleus. J Neuroimmune Pharmacol. 2015;10(1):35-44. doi:10.1007/s11481-014-9568-7
Zamora NN, Cheli VT, González DAS, Wan R, Paez PM. Deletion of voltage-gated calcium channels in astrocytes during demyelination reduces brain inflammation and promotes myelin regeneration in mice. J Neurosci. 2020;40(17):3332-3347. doi:10.1523/JNEUROSCI.1644-19.2020
Leisz S, Simmermacher S, Prell J, Strauss C, Scheller C. Dihydropyridines allosterically modulate Hsp90 providing a novel mechanism for heat shock protein co-induction and neuroprotection. Int J Mol Sci. 2019;20(18):4578. doi:10.3390/ijms20184578
Yoo J-M, Lee BD, Sok D-E, Ma JY, Kim MR. Neuroprotective action of N-acetyl serotonin in oxidative stress-induced apoptosis through the activation of both TrkB/CREB/BDNF pathway and Akt/Nrf2/antioxidant enzyme in neuronal cells. Redox Biol. 2017;11:592-599. doi:10.1016/j.redox.2016.12.034
Kusakabe M, Hasegawa Y. Nimodipine promotes neurite outgrowth and protects against neurotoxicity in PC12 cells. Iran J Basic Med Sci. 2021;24:51.