Mammalian derived lipocalin and secretoglobin respiratory allergens strongly bind ligands with potentially immune modulating properties.
Cav p 1 crystal structure
farnesol
fluorescence-quenching assays
lipocalin
mammalian respiratory allergens
protein-ligand interactions
secretoglobin
Journal
Frontiers in allergy
ISSN: 2673-6101
Titre abrégé: Front Allergy
Pays: Switzerland
ID NLM: 9918227355906676
Informations de publication
Date de publication:
2022
2022
Historique:
received:
31
05
2022
accepted:
12
07
2022
entrez:
22
8
2022
pubmed:
23
8
2022
medline:
23
8
2022
Statut:
epublish
Résumé
Allergens from furry animals frequently cause sensitization and respiratory allergic diseases. Most relevant mammalian respiratory allergens belong either to the protein family of lipocalins or secretoglobins. Their mechanism of sensitization remains largely unresolved. Mammalian lipocalin and secretoglobin allergens are associated with a function in chemical communication that involves abundant secretion into the environment, high stability and the ability to transport small volatile compounds. These properties are likely to contribute concomitantly to their allergenic potential. In this study, we aim to further elucidate the physiological function of lipocalin and secretoglobin allergens and link it to their sensitizing capacity, by analyzing their ligand-binding characteristics. We produced eight major mammalian respiratory allergens from four pet species in
Identifiants
pubmed: 35991307
doi: 10.3389/falgy.2022.958711
pmc: PMC9385959
doi:
Types de publication
Journal Article
Langues
eng
Pagination
958711Informations de copyright
Copyright © 2022 Janssen-Weets, Kerff, Swiontek, Kler, Czolk, Revets, Kuehn, Bindslev-Jensen, Ollert and Hilger.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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