Serial liver transaminases have no prognostic value in non-alcoholic fatty liver disease.
fatty liver disease
liver enzymes
natural history
Journal
Canadian liver journal
ISSN: 2561-4444
Titre abrégé: Can Liver J
Pays: Canada
ID NLM: 101778326
Informations de publication
Date de publication:
2019
2019
Historique:
received:
04
04
2018
accepted:
07
04
2018
entrez:
22
8
2022
pubmed:
25
2
2019
medline:
25
2
2019
Statut:
epublish
Résumé
Routine measurement of liver transaminases is common in the general monitoring of patients with non-alcoholic fatty liver disease (NAFLD), but there is little data to support the utility of this practice. The aims of this study were to determine how alanine aminotransferase (ALT) results vary over time in patients with NAFLD; and to determine if serial measurement of ALT is a useful clinical marker for progression of NAFLD. Consecutive adult patients with NAFLD were followed prospectively in a tertiary liver disease clinic over a 15-year period. Clinicodemographic characteristics and the change in liver enzymes, liver function, and histopathology were followed over time. Paired A change in liver transaminases over time is not a useful metric in predicting outcomes in patients with NAFLD. Additionally, all stages of NAFLD are equally responsive to standard medical interventions of advocating for weight loss and correcting metabolic disturbances.
Sections du résumé
Background
UNASSIGNED
Routine measurement of liver transaminases is common in the general monitoring of patients with non-alcoholic fatty liver disease (NAFLD), but there is little data to support the utility of this practice. The aims of this study were to determine how alanine aminotransferase (ALT) results vary over time in patients with NAFLD; and to determine if serial measurement of ALT is a useful clinical marker for progression of NAFLD.
Methods
UNASSIGNED
Consecutive adult patients with NAFLD were followed prospectively in a tertiary liver disease clinic over a 15-year period. Clinicodemographic characteristics and the change in liver enzymes, liver function, and histopathology were followed over time. Paired
Results/Conclusion
UNASSIGNED
A change in liver transaminases over time is not a useful metric in predicting outcomes in patients with NAFLD. Additionally, all stages of NAFLD are equally responsive to standard medical interventions of advocating for weight loss and correcting metabolic disturbances.
Identifiants
pubmed: 35991834
doi: 10.3138/canlivj.2018-0006
pmc: PMC9202679
doi:
Types de publication
Journal Article
Langues
eng
Pagination
19-22Informations de copyright
Copyright © 2019 Canadian Association for the Study of the Liver.
Déclaration de conflit d'intérêts
The authors have nothing to disclose.
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