Building Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances "Take a Village".

antiparasitic treatment congenital toxoplasmosis diagnostic testing marginalized populations point-of-care testing prenatal screening

Journal

Current pediatrics reports
ISSN: 2167-4841
Titre abrégé: Curr Pediatr Rep
Pays: Germany
ID NLM: 101600850

Informations de publication

Date de publication:
2022
Historique:
accepted: 29 04 2022
pubmed: 23 8 2022
medline: 23 8 2022
entrez: 22 8 2022
Statut: ppublish

Résumé

Review international efforts to build a global public health initiative focused on toxoplasmosis with spillover benefits to save lives, sight, cognition and motor function benefiting maternal and child health. Multiple countries' efforts to eliminate toxoplasmosis demonstrate progress and context for this review and new work. Problems with potential solutions proposed include accessibility of accurate, inexpensive diagnostic testing, pre-natal screening and facilitating tools, missed and delayed neonatal diagnosis, restricted access, high costs, delays in obtaining medicines emergently, delayed insurance pre-approvals and high medicare copays taking considerable physician time and effort, harmful shortcuts being taken in methods to prepare medicines in settings where access is restricted, reluctance to perform ventriculoperitoneal shunts promptly when needed without recognition of potential benefit, access to resources for care, especially for marginalized populations, and limited use of recent advances in management of neurologic and retinal disease which can lead to good outcomes. The online version contains supplementary material available at 10.1007/s40124-022-00268-x.

Identifiants

pubmed: 35991908
doi: 10.1007/s40124-022-00268-x
pii: 268
pmc: PMC9379243
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

125-154

Informations de copyright

© The Author(s) 2022.

Déclaration de conflit d'intérêts

Conflict of Interest/Competing Interests There are no other disclosures and no other competing interests.

Références

J Lab Clin Med. 1990 Nov;116(5):623-35
pubmed: 2146348
Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13192-7
pubmed: 16920791
Vaccine. 2010 May 21;28(23):3977-89
pubmed: 20347630
Lancet. 1986 Feb 1;1(8475):254-6
pubmed: 2868264
Am J Obstet Gynecol. 2006 Mar;194(3):907; author reply 907-8
pubmed: 16522442
Semin Pediatr Neurol. 1994 Sep;1(1):4-25
pubmed: 9422215
PLoS Negl Trop Dis. 2008 Mar 05;2(3):e190
pubmed: 18320016
Heliyon. 2021 Apr 05;7(4):e06659
pubmed: 33898813
Clin Infect Dis. 2006 May 15;42(10):1383-94
pubmed: 16619149
Clin Infect Dis. 1996 Nov;23(5):1055-60
pubmed: 8922802
Front Cell Infect Microbiol. 2018 Oct 05;8:352
pubmed: 30345257
Clin Infect Dis. 2013 May;56(9):1223-31
pubmed: 23362291
PLoS Negl Trop Dis. 2011 Sep;5(9):e1333
pubmed: 21980546
Emerg Infect Dis. 2006 Feb;12(2):326-9
pubmed: 16494765
Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13387-92
pubmed: 10557330
Infect Immun. 2014 Jul;82(7):2670-9
pubmed: 24686056
Infect Immun. 2012 Dec;80(12):4298-308
pubmed: 23027530
Clin Infect Dis. 2015 Dec 15;61(12):1815-24
pubmed: 26405150
Mol Biochem Parasitol. 2001 Nov;118(1):23-32
pubmed: 11704270
Bull World Health Organ. 2017 Sep 1;95(9):639-645
pubmed: 28867844
Eur J Clin Microbiol Infect Dis. 2019 May;38(5):883-890
pubmed: 30701339
Parasitol Today. 1999 Feb;15(2):51-7
pubmed: 10234186
Emerg Microbes Infect. 2018 Sep 27;7(1):165
pubmed: 30262847
Clin Infect Dis. 2016 Mar 15;62(6):812-4
pubmed: 26689955
J Infect Dis. 2006 Oct 15;194(8):1176-83
pubmed: 16991094
Cell. 2020 Jan 23;180(2):359-372.e16
pubmed: 31955846
Genes Immun. 2010 Jul;11(5):374-83
pubmed: 20535134
Eur J Med Res. 2021 Dec 11;26(1):143
pubmed: 34895348
Pediatr Infect Dis J. 2006 Mar;25(3):270-2
pubmed: 16511396
Vet Parasitol. 2017 Oct 15;245:160-162
pubmed: 28624132
Pediatrics. 2006 Aug;118(2):e379-90
pubmed: 16864640
PLoS Negl Trop Dis. 2008 Jun 25;2(6):e256
pubmed: 18575621
PLoS One. 2008 Jun 04;3(6):e2285
pubmed: 18523590
Parasitology. 2001 Nov;123(Pt 5):433-9
pubmed: 11719953
N Engl J Med. 1994 Jun 30;330(26):1858-63
pubmed: 7818637
Clin Infect Dis. 1994 Jan;18(1):38-72
pubmed: 8054436
Nature. 1998 Jun 25;393(6687):801-5
pubmed: 9655396
Gene. 1997 Jan 3;184(1):1-12
pubmed: 9016946
Parasitology. 2021 Oct;148(12):1406-1416
pubmed: 34254575
Antimicrob Agents Chemother. 2012 May;56(5):2666-82
pubmed: 22354304
Infect Immun. 2018 Mar 22;86(4):
pubmed: 29426041
Mem Inst Oswaldo Cruz. 2009 Mar;104(2):162-9
pubmed: 19430638
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14281-6
pubmed: 14623959
Open Forum Infect Dis. 2018 Oct 29;5(10):ofy215
pubmed: 30393749
Emerg Microbes Infect. 2021 Dec;10(1):1675-1682
pubmed: 34165384
J Neuroparasitology. 2012 Mar;3(2012):
pubmed: 23487348
J Comput Aided Mol Des. 2011 May;25(5):403-11
pubmed: 21359560
Antimicrob Agents Chemother. 1992 May;36(5):1040-8
pubmed: 1510391
Vaccine. 2011 Jan 17;29(4):754-62
pubmed: 21095258
Immunome Res. 2010 Dec 03;6:12
pubmed: 21129215
PLoS One. 2022 Nov 4;17(11):"e0273781"
pubmed: 36331943
J Pediatr (Rio J). 2014 Jul-Aug;90(4):329-31
pubmed: 24726454
Pathogens. 2021 Jun 17;10(6):
pubmed: 34204401
PLoS Negl Trop Dis. 2017 Jul 10;11(7):e0005648
pubmed: 28692640
Front Immunol. 2019 Feb 14;10:77
pubmed: 30891027
Am J Obstet Gynecol. 2005 Feb;192(2):564-71
pubmed: 15696004
Hum Immunol. 2012 Jan;73(1):1-10
pubmed: 22027386
J Immunol. 2010 Jun 15;184(12):7040-6
pubmed: 20488797
Am J Ophthalmol. 2003 Jun;135(6):779-84
pubmed: 12788116
Clin Infect Dis. 2012 Jun;54(11):1595-605
pubmed: 22499837
Ocul Immunol Inflamm. 2011 Apr;19(2):91-102
pubmed: 21428746
Clin Infect Dis. 2011 Dec;53(11):1081-9
pubmed: 22021924
Pediatrics. 1980 Nov;66(5):767-74
pubmed: 7432882
Int J Parasitol. 1999 Sep;29(9):1351-8
pubmed: 10579423
PLoS Negl Trop Dis. 2017 Feb 16;11(2):e0005222
pubmed: 28207736
Am J Ophthalmol. 2008 Sep;146(3):375-384
pubmed: 18619570
Ophthalmology. 2008 Mar;115(3):553-559.e8
pubmed: 17825418
Front Cell Infect Microbiol. 2020 Jun 09;10:203
pubmed: 32626661
J Pediatr. 2021 Sep;236:301-306
pubmed: 34023345
Infect Immun. 2011 Feb;79(2):756-66
pubmed: 21098108
Clin Chim Acta. 2017 Jan;464:200-201
pubmed: 27765564
Sci Rep. 2020 Oct 12;10(1):16984
pubmed: 33046728
Am Rev Respir Dis. 1983 Jul;128(1):182-5
pubmed: 6408961
PLoS Negl Trop Dis. 2019 Oct 14;13(10):e0007807
pubmed: 31609966
Radiology. 1996 May;199(2):433-40
pubmed: 8668790
Pediatr Infect Dis J. 2021 Jan;40(1):e21-e27
pubmed: 33060522
Vaccines (Basel). 2021 Apr 21;9(5):
pubmed: 33919060
Antimicrob Agents Chemother. 2006 Aug;50(8):2713-8
pubmed: 16870763
Pediatr Infect Dis J. 2008 Jan;27(1):27-32
pubmed: 18162934
Mediators Inflamm. 2014;2014:910621
pubmed: 25328286
Sci Rep. 2019 Feb 6;9(1):1474
pubmed: 30728393
Clin Infect Dis. 2016 Aug 15;63(4):468-75
pubmed: 27353665
J AAPOS. 2007 Dec;11(6):551-4
pubmed: 18086432
Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15936-41
pubmed: 23019377
J Infect Dis. 2015 Jun 15;211(12):2006-13
pubmed: 25538275
Antimicrob Agents Chemother. 2014;58(3):1789-92
pubmed: 24366743
Pediatrics. 1995 Jan;95(1):11-20
pubmed: 7770286
PLoS One. 2010 Nov 22;5(11):e14057
pubmed: 21124925
J Med Chem. 2010 Sep 9;53(17):6287-300
pubmed: 20698542
PLoS Negl Trop Dis. 2017 Jun 26;11(6):e0005670
pubmed: 28650970
Am J Ophthalmol. 1996 Sep;122(3):309-24
pubmed: 8794703
Gynecol Obstet Fertil Senol. 2021 Oct;49(10):782-791
pubmed: 33677120
PLoS Negl Trop Dis. 2018 Aug 16;12(8):e0006536
pubmed: 30114251
Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14182-7
pubmed: 22891343
Diagn Microbiol Infect Dis. 2017 Mar;87(3):213-218
pubmed: 28040304
ACS Chem Biol. 2013;8(6):1155-62
pubmed: 23530747
Parasitology. 2012 Sep;139(11):1375-424
pubmed: 22776427
J Parasitol. 2011 Apr;97(2):328-37
pubmed: 21506817
Sci Med (Porto Alegre). 2010;20(1):20-26
pubmed: 22577474
Ann Intern Med. 1979 Jan;90(1):47-9
pubmed: 369424
Otolaryngol Head Neck Surg. 1992 Jan;106(1):75-80
pubmed: 1734373
Clin Infect Dis. 2015 Dec 15;61(12):1831-4
pubmed: 26405147
ACS Med Chem Lett. 2016 Sep 17;7(12):1124-1129
pubmed: 27994750
Arch Ophthalmol. 2008 Aug;126(8):1152-6
pubmed: 18695115
NPJ Vaccines. 2017 Sep 5;2:24
pubmed: 29263879
JCI Insight. 2016 Sep 22;1(15):e85955
pubmed: 27699241
Sci Rep. 2016 Jul 14;6:29179
pubmed: 27412848
Elife. 2021 Apr 27;10:
pubmed: 33904393

Auteurs

Mariangela Soberón Felín (MS)

Toxoplasmosis Programs and Initiatives in Panama, Ciudad de Panama, Panama.

Kanix Wang (K)

Institute for Genomics and Systems Biology, The University of Chicago, Chicago, IL USA.

Aliya Moreira (A)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.
Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT-AIP), Ciudad de Panama, Panama.
Department of Pediatrics Infectious Diseases/Department of Neonatology, Hospital del Niño doctor José Renán Esquivel, Ciudad de Panama, Panama.
Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.
The College, The University of Chicago, Chicago, IL USA.
The Global Health Center, The University of Chicago, Chicago, IL USA.

Andrew Grose (A)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.
Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.
The Global Health Center, The University of Chicago, Chicago, IL USA.

Karen Leahy (K)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.

Ying Zhou (Y)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.
Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.

Fatima Alibana Clouser (FA)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.
Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.

Maryam Siddiqui (M)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.

Nicole Leong (N)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.

Perpetua Goodall (P)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.

Morgan Michalowski (M)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.

Mahmoud Ismail (M)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.

Monica Christmas (M)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.

Stephen Schrantz (S)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.

Zuleima Caballero (Z)

Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT-AIP), Ciudad de Panama, Panama.

Ximena Norero (X)

Department of Pediatrics Infectious Diseases/Department of Neonatology, Hospital del Niño doctor José Renán Esquivel, Ciudad de Panama, Panama.

Dora Estripeaut (D)

Department of Pediatrics Infectious Diseases/Department of Neonatology, Hospital del Niño doctor José Renán Esquivel, Ciudad de Panama, Panama.

David Ellis (D)

Department of Pediatrics Infectious Diseases/Department of Neonatology, Hospital del Niño doctor José Renán Esquivel, Ciudad de Panama, Panama.

Catalina Raggi (C)

Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.
The College, The University of Chicago, Chicago, IL USA.
The Global Health Center, The University of Chicago, Chicago, IL USA.

Catherine Castro (C)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.
Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.
The Global Health Center, The University of Chicago, Chicago, IL USA.

Davina Moossazadeh (D)

Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.
The College, The University of Chicago, Chicago, IL USA.
The Global Health Center, The University of Chicago, Chicago, IL USA.
Department of Statistics, The University of Chicago, Chicago, IL USA.

Margarita Ramirez (M)

Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.
The College, The University of Chicago, Chicago, IL USA.
The Global Health Center, The University of Chicago, Chicago, IL USA.

Abhinav Pandey (A)

Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.
The College, The University of Chicago, Chicago, IL USA.
The Global Health Center, The University of Chicago, Chicago, IL USA.

Kevin Ashi (K)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.
Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.
The Global Health Center, The University of Chicago, Chicago, IL USA.

Samantha Dovgin (S)

Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.
The College, The University of Chicago, Chicago, IL USA.

Ashtyn Dixon (A)

Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.

Xuan Li (X)

Rush University Medical School/Rush University Medical Center, Chicago, IL USA.

Ian Begeman (I)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.
Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.

Sharon Heichman (S)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.
Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.

Joseph Lykins (J)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.
Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.

Delba Villalobos-Cerrud (D)

Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT-AIP), Ciudad de Panama, Panama.

Lorena Fabrega (L)

Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT-AIP), Ciudad de Panama, Panama.

José Luis Sanchez Montalvo (JLS)

Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.
The College, The University of Chicago, Chicago, IL USA.
The Global Health Center, The University of Chicago, Chicago, IL USA.

Connie Mendivil (C)

Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT-AIP), Ciudad de Panama, Panama.

Mario R Quijada (MR)

Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT-AIP), Ciudad de Panama, Panama.

Silvia Fernández-Pirla (S)

Toxoplasmosis Programs and Initiatives in Panama, Ciudad de Panama, Panama.
Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT-AIP), Ciudad de Panama, Panama.
Academia Interamericana de Panama, Ciudad de Panama, Panama.

Valli de La Guardia (V)

Toxoplasmosis Programs and Initiatives in Panama, Ciudad de Panama, Panama.
Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT-AIP), Ciudad de Panama, Panama.
Hospital Santo Tomás, Ciudad de Panama, Panama.
Hospital San Miguel Arcángel, Ciudad de Panama, Panama.

Digna Wong (D)

Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT-AIP), Ciudad de Panama, Panama.

Mayrene Ladrón de Guevara (ML)

Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT-AIP), Ciudad de Panama, Panama.
Hospital Santo Tomás, Ciudad de Panama, Panama.

Carlos Flores (C)

Hospital Santo Tomás, Ciudad de Panama, Panama.

Jovanna Borace (J)

Hospital Santo Tomás, Ciudad de Panama, Panama.

Anabel García (A)

Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT-AIP), Ciudad de Panama, Panama.

Natividad Caballero (N)

Hospital San Miguel Arcángel, Ciudad de Panama, Panama.

Claudia Rengifo-Herrera (C)

Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT-AIP), Ciudad de Panama, Panama.
Universidad de Panama, Ciudad de Panama, Panama.

Maria Theresa Moreno de Saez (MTM)

Department of Pediatrics Infectious Diseases/Department of Neonatology, Hospital del Niño doctor José Renán Esquivel, Ciudad de Panama, Panama.

Michael Politis (M)

Toxoplasmosis Programs and Initiatives in Panama, Ciudad de Panama, Panama.

Stephanie Ross (S)

Rush University Medical School/Rush University Medical Center, Chicago, IL USA.

Mimansa Dogra (M)

Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.
The College, The University of Chicago, Chicago, IL USA.
The Global Health Center, The University of Chicago, Chicago, IL USA.

Vishan Dhamsania (V)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.
Global Health Center Capstone Program, The University of Chicago, Chicago, IL USA.

Nicholas Graves (N)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.
Global Health Center Capstone Program, The University of Chicago, Chicago, IL USA.

Marci Kirchberg (M)

Global Health Center Capstone Program, The University of Chicago, Chicago, IL USA.
Harris School of Public Policy, The University of Chicago, Chicago, IL USA.

Kopal Mathur (K)

Global Health Center Capstone Program, The University of Chicago, Chicago, IL USA.
Harris School of Public Policy, The University of Chicago, Chicago, IL USA.

Ashley Aue (A)

The Global Health Center, The University of Chicago, Chicago, IL USA.
Harris School of Public Policy, The University of Chicago, Chicago, IL USA.

Carlos M Restrepo (CM)

Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT-AIP), Ciudad de Panama, Panama.

Alejandro Llanes (A)

Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT-AIP), Ciudad de Panama, Panama.

German Guzman (G)

Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT-AIP), Ciudad de Panama, Panama.

Arturo Rebellon (A)

Sanofi Aventis de Panama S.A., University of South Florida, Ciudad de Panama, Panama.

Kenneth Boyer (K)

Rush University Medical School/Rush University Medical Center, Chicago, IL USA.

Peter Heydemann (P)

Rush University Medical School/Rush University Medical Center, Chicago, IL USA.

A Gwendolyn Noble (AG)

Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.
Northwestern University Feinberg School of Medicine, Chicago, IL USA.

Charles Swisher (C)

Northwestern University Feinberg School of Medicine, Chicago, IL USA.

Peter Rabiah (P)

NorthShore Evanston Hospital, Evanston, IL USA.

Shawn Withers (S)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.
Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.

Teri Hull (T)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.

David Frim (D)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.

David McLone (D)

Northwestern University Feinberg School of Medicine, Chicago, IL USA.

Chunlei Su (C)

Department of Microbiology, The University of Tennessee, Knoxville, TN USA.

Michael Blair (M)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.
Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.

Paul Latkany (P)

Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.

Ernest Mui (E)

Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.

Daniel Vitor Vasconcelos-Santos (DV)

Universidad de Federal de Minas Gerais, Minas Gerais, Brazil.

Alcibiades Villareal (A)

Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT-AIP), Ciudad de Panama, Panama.

Ambar Perez (A)

Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT-AIP), Ciudad de Panama, Panama.

Carlos Andrés Naranjo Galvis (CAN)

Universidad Autónoma de Manizales, Manizales, Colombia.

Mónica Vargas Montes (MV)

Universidad del Quindío, Armenia, Colombia.

Nestor Ivan Cardona Perez (NIC)

Universidad del Quindío, Armenia, Colombia.

Morgan Ramirez (M)

Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.
The College, The University of Chicago, Chicago, IL USA.

Cy Chittenden (C)

Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.
The College, The University of Chicago, Chicago, IL USA.

Edward Wang (E)

Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.
The College, The University of Chicago, Chicago, IL USA.

Laura Lorena Garcia-López (LL)

Universidad del Quindío, Armenia, Colombia.

Guillermo Padrieu (G)

The University of South Florida College of Public Health, Tampa, FL USA.

Juliana Muñoz-Ortiz (J)

Grupo de Investigación en Neurociencias, Universidad del Rosario, Bogotá, Colombia.

Nicolás Rivera-Valdivia (N)

Grupo de Investigación en Neurociencias, Universidad del Rosario, Bogotá, Colombia.

María Cristina Bohorquez-Granados (MC)

Grupo de Investigación en Neurociencias, Universidad del Rosario, Bogotá, Colombia.

Gabriela Castaño de-la-Torre (GC)

Grupo de Investigación en Neurociencias, Universidad del Rosario, Bogotá, Colombia.

Juan David Valencia Hernandez (JDV)

Universidad del Quindío, Armenia, Colombia.

Daniel Celis-Giraldo (D)

Universidad del Quindío, Armenia, Colombia.

Juan Alejandro Acosta Dávila (JAA)

Grupo de Investigación en Neurociencias, Universidad del Rosario, Bogotá, Colombia.

Elizabeth Torres (E)

Universidad del Quindío, Armenia, Colombia.

Manuela Mejia Oquendo (MM)

Universidad del Quindío, Armenia, Colombia.

José Y Arteaga-Rivera (JY)

Grupo de Investigación en Neurociencias, Universidad del Rosario, Bogotá, Colombia.

Dan L Nicolae (DL)

Department of Statistics, The University of Chicago, Chicago, IL USA.

Andrey Rzhetsky (A)

Institute for Genomics and Systems Biology, The University of Chicago, Chicago, IL USA.

Nancy Roizen (N)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.

Eileen Stillwaggon (E)

Department of Economics, Gettysburg College, Gettysburg, PA USA.

Larry Sawers (L)

Department of Economics, American University, Washington, DC USA.

Francois Peyron (F)

Institut des agents infectieux, Hôpital de la Croix-Rousse, Lyon, France.

Martine Wallon (M)

Institut des agents infectieux, Hôpital de la Croix-Rousse, Lyon, France.

Emanuelle Chapey (E)

Institut des agents infectieux, Hôpital de la Croix-Rousse, Lyon, France.

Pauline Levigne (P)

Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.
Institut des agents infectieux, Hôpital de la Croix-Rousse, Lyon, France.

Carmen Charter (C)

Hospital Santo Tomás, Ciudad de Panama, Panama.

Migdalia De Frias (M)

Hospital Santo Tomás, Ciudad de Panama, Panama.

Jose Montoya (J)

Remington Specialty Laboratory, Palo Alto, CA USA.

Cindy Press (C)

Remington Specialty Laboratory, Palo Alto, CA USA.

Raymund Ramirez (R)

Remington Specialty Laboratory, Palo Alto, CA USA.

Despina Contopoulos-Ioannidis (D)

Department of Pediatrics, Division of Infectious Diseases, Stanford University College of Medicine, Stanford, CA USA.

Yvonne Maldonado (Y)

Department of Pediatrics, Division of Infectious Diseases, Stanford University College of Medicine, Stanford, CA USA.

Oliver Liesenfeld (O)

Roche Molecular Diagnostics, Pleasanton, CA USA.

Carlos Gomez (C)

Department of Pediatrics, Division of Infectious Diseases, Stanford University College of Medicine, Stanford, CA USA.

Kelsey Wheeler (K)

Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.
The College, The University of Chicago, Chicago, IL USA.

Samantha Zehar (S)

Northwestern University Feinberg School of Medicine, Chicago, IL USA.

James McAuley (J)

Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.

Denis Limonne (D)

LDBioDiagnostics, Lyon, France.

Sandrine Houze (S)

Laboratory of Parasitologie, Bichat-Claude Bernard Hopital, Paris, France.

Sylvie Abraham (S)

Laboratory of Parasitologie, Bichat-Claude Bernard Hopital, Paris, France.

Raphael Piarroux (R)

LDBioDiagnostics, Lyon, France.

Vera Tesic (V)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.

Kathleen Beavis (K)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.

Ana Abeleda (A)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.

Mari Sautter (M)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.

Bouchra El Mansouri (B)

INH, Rabat, Morocco.

Adlaoui El Bachir (A)

INH, Rabat, Morocco.

Fatima Amarir (F)

Faculty of Sciences Ain Chock, University Hassan II, Casablanca, Morocco.

Kamal El Bissati (K)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.
Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.
INH, Rabat, Morocco.

Ellen Holfels (E)

Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.

David Frim (D)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.

David McLone (D)

Northwestern University Feinberg School of Medicine, Chicago, IL USA.

Richard Penn (R)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.

William Cohen (W)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.
Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.
The College, The University of Chicago, Chicago, IL USA.

Alejandra de-la-Torre (A)

Grupo de Investigación en Neurociencias, Universidad del Rosario, Bogotá, Colombia.

Gabrielle Britton (G)

Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT-AIP), Ciudad de Panama, Panama.
Sistema Nacional de investigadores de Panama (SNI), Panama, Panama.

Jorge Motta (J)

Secretaría Nacional de Ciencia, Tecnología e Innovación (SENACYT), Ciudad de Panama, Panama.

Eduardo Ortega-Barria (E)

Sistema Nacional de investigadores de Panama (SNI), Panama, Panama.
Secretaría Nacional de Ciencia, Tecnología e Innovación (SENACYT), Ciudad de Panama, Panama.
GSK Vaccines, Panama, Panama.

Isabel Luz Romero (IL)

Secretaría Nacional de Ciencia, Tecnología e Innovación (SENACYT), Ciudad de Panama, Panama.

Paul Meier (P)

Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.

Michael Grigg (M)

Molecular Parasitology, NIAID,NIH, Bethesda, MD USA.

Jorge Gómez-Marín (J)

Universidad del Quindío, Armenia, Colombia.

Jagannatha Rao Kosagisharaf (JR)

Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT-AIP), Ciudad de Panama, Panama.
Sistema Nacional de investigadores de Panama (SNI), Panama, Panama.

Xavier Sáez Llorens (XS)

Department of Pediatrics Infectious Diseases/Department of Neonatology, Hospital del Niño doctor José Renán Esquivel, Ciudad de Panama, Panama.
Sistema Nacional de investigadores de Panama (SNI), Panama, Panama.

Osvaldo Reyes (O)

Hospital Santo Tomás, Ciudad de Panama, Panama.
Universidad de Panama, Ciudad de Panama, Panama.
Sistema Nacional de investigadores de Panama (SNI), Panama, Panama.

Rima McLeod (R)

Toxoplasmosis Programs and Initiatives in Panama, Ciudad de Panama, Panama.
Institute for Genomics and Systems Biology, The University of Chicago, Chicago, IL USA.
Pritzker School of Medicine, The University of Chicago, Chicago, IL USA.
Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL USA.
The College, The University of Chicago, Chicago, IL USA.
The Global Health Center, The University of Chicago, Chicago, IL USA.
Toxoplasmosis Center, The University of Chicago and Toxoplasmosis Research Institute, Chicago, IL USA.
Department of Pediatrics (Infectious Diseases), The University of Chicago, Chicago, IL USA.

Classifications MeSH