Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST
FLNA
GPCR dimerization
SST2
SST5
in situ PLA
somatostatin analogs
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2022
2022
Historique:
received:
17
03
2022
accepted:
08
07
2022
entrez:
22
8
2022
pubmed:
23
8
2022
medline:
24
8
2022
Statut:
epublish
Résumé
The process of GPCR dimerization can have profound effects on GPCR activation, signaling, and intracellular trafficking. Somatostatin receptors (SSTs) are class A GPCRs abundantly expressed in pituitary tumors where they represent the main pharmacological targets of somatostatin analogs (SSAs), thanks to their antisecretory and antiproliferative actions. The cytoskeletal protein filamin A (FLNA) directly interacts with both somatostatin receptor type 2 (SST
Identifiants
pubmed: 35992099
doi: 10.3389/fendo.2022.892668
pmc: PMC9389162
doi:
Substances chimiques
FLNA protein, human
0
Filamins
0
Somatostatin
51110-01-1
Octreotide
RWM8CCW8GP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
892668Informations de copyright
Copyright © 2022 Treppiedi, Marra, Di Muro, Catalano, Mangili, Esposito, Calebiro, Arosio, Peverelli and Mantovani.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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