BECN1
Aging
BECN1
autophagic flux
liver
mouse
skeletal muscle
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
pubmed:
23
8
2022
medline:
3
3
2023
entrez:
22
8
2022
Statut:
ppublish
Résumé
Macroautophagy/autophagy is necessary for lifespan extension in multiple model organisms and autophagy dysfunction impacts age-related phenotypes and diseases. Introduction of an F121A mutation into the essential autophagy protein BECN1 constitutively increases basal autophagy in young mice and reduces cardiac and renal age-related changes in longer lived
Identifiants
pubmed: 35993269
doi: 10.1080/15548627.2022.2111852
pmc: PMC9980460
doi:
Substances chimiques
Becn1 protein, mouse
0
Beclin-1
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
957-965Subventions
Organisme : NIAID NIH HHS
ID : U19 AI142784
Pays : United States
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