Premature aging is associated with higher levels of 8-oxoguanine and increased DNA damage in the Polg mutator mouse.
8-oxoguanine
aging
mitochondria
oxidative stress
telomeres
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
revised:
07
06
2022
received:
11
02
2022
accepted:
24
06
2022
pubmed:
23
8
2022
medline:
16
9
2022
entrez:
22
8
2022
Statut:
ppublish
Résumé
Mitochondrial dysfunction plays an important role in the aging process. However, the mechanism by which this dysfunction causes aging is not fully understood. The accumulation of mutations in the mitochondrial genome (or "mtDNA") has been proposed as a contributor. One compelling piece of evidence in support of this hypothesis comes from the Polg
Identifiants
pubmed: 35993394
doi: 10.1111/acel.13669
pmc: PMC9470903
doi:
Substances chimiques
DNA, Mitochondrial
0
8-hydroxyguanine
5614-64-2
Guanine
5Z93L87A1R
DNA Polymerase gamma
EC 2.7.7.7
DNA-Directed DNA Polymerase
EC 2.7.7.7
Polg protein, mouse
EC 2.7.7.7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13669Subventions
Organisme : NIA NIH HHS
ID : F32 AG067710
Pays : United States
Organisme : NIEHS NIH HHS
ID : K99 ES033771
Pays : United States
Organisme : NIEHS NIH HHS
ID : R35 ES030396
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG061408
Pays : United States
Informations de copyright
© 2022 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.
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