Acceptability of PC-1005 Gel Administered Rectally to HIV-1 Seronegative Adults at Three Different Volume Levels (MTN-037).


Journal

AIDS education and prevention : official publication of the International Society for AIDS Education
ISSN: 1943-2755
Titre abrégé: AIDS Educ Prev
Pays: United States
ID NLM: 9002873

Informations de publication

Date de publication:
08 2022
Historique:
entrez: 22 8 2022
pubmed: 23 8 2022
medline: 25 8 2022
Statut: ppublish

Résumé

Multipurpose prevention technologies (MPT) have been increasingly researched for their dual-purpose preventative properties against HIV and other STIs. The acceptability of PC-1005, a topical MPT candidate, was explored among men and women participating in the MTN-037 Phase I trial at two U.S. sites (Pittsburgh, PA, and Birmingham, AL). We triangulated quantitative and qualitative assessments of the acceptability of three volumes (4 mL, 16 mL, 32 mL) of PC-1005 administered rectally (N = 12; 6 males, 6 females). Participants rated overall gel acceptability on a scale of 1-10, with a median of 7.17 (

Identifiants

pubmed: 35994578
doi: 10.1521/aeap.2022.34.4.257
pmc: PMC9924357
mid: NIHMS1871492
doi:

Types de publication

Clinical Trial, Phase I Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

257-271

Subventions

Organisme : NIAID NIH HHS
ID : UM1 AI068633
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI069494
Pays : United States

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Auteurs

José A Bauermeister (JA)

University of Pennsylvania, Philadelphia, Pennsylvania.

Ryan C Tingler (RC)

University of Pennsylvania, Philadelphia, Pennsylvania.

Ken Ho (K)

University of Pittsburgh, Pittsburgh, Pennsylvania.

Rachel Scheckter (R)

FHI 360, Durham, North Carolina.

Tara McClure (T)

FHI 360, Durham, North Carolina.

Jontraye Davis (J)

FHI 360, Durham, North Carolina.

Jeanna Piper (J)

Division of AIDS/NIAID/NIH, Bethesda, Maryland.

Barbara A Friedland (BA)

Population Council, Center for Biomedical Research, New York, New York.

Stacey Edick (S)

University of Pittsburgh, Pittsburgh, Pennsylvania.

Mei Song (M)

Microbicide Trials Network, Pittsburgh, Pennsylvania.

Yuqing Jiao (Y)

Fred Hutchinson Cancer Research Center, Seattle, Washington.

Craig W Hendrix (CW)

Johns Hopkins University School of Medicine, Baltimore, Maryland.

Craig Hoesley (C)

University of Alabama at Birmingham, Birmingham, Alabama.

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Classifications MeSH