SARS-CoV-2 causes secretory diarrhea with an enterotoxin-like mechanism, which is reduced by diosmectite.
COVID-19
Diosmectite
Gastroenteritis
Oxidative stress
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
21
12
2021
revised:
25
02
2022
accepted:
05
08
2022
entrez:
23
8
2022
pubmed:
24
8
2022
medline:
24
8
2022
Statut:
ppublish
Résumé
The pathophysiology of SARS-CoV-2-associated diarrhea is unknown. Using an experimental model validated for rotavirus-induced diarrhea, we investigated the effects of SARS-CoV-2 on transepithelial ion fluxes and epithelial integrity of human intestinal cells. The effect of the antidiarrheal agent diosmectite on secretion was also evaluated following its inclusion in COVID-19 management protocols. We evaluated electrical parameters (intensity of short-circuit current [ hiSARS-CoV-2 induced an increase in SARS-CoV-2 induces calcium-dependent chloride secretion and oxidative stress without damaging intestinal epithelial structure. The effects are largely induced by the spike protein and are significantly reduced by diosmectite. SARS-CoV-2 should be added to the list of human enteric pathogens.
Sections du résumé
Background and aims
UNASSIGNED
The pathophysiology of SARS-CoV-2-associated diarrhea is unknown. Using an experimental model validated for rotavirus-induced diarrhea, we investigated the effects of SARS-CoV-2 on transepithelial ion fluxes and epithelial integrity of human intestinal cells. The effect of the antidiarrheal agent diosmectite on secretion was also evaluated following its inclusion in COVID-19 management protocols.
Methods
UNASSIGNED
We evaluated electrical parameters (intensity of short-circuit current [
Results
UNASSIGNED
hiSARS-CoV-2 induced an increase in
Conclusions
UNASSIGNED
SARS-CoV-2 induces calcium-dependent chloride secretion and oxidative stress without damaging intestinal epithelial structure. The effects are largely induced by the spike protein and are significantly reduced by diosmectite. SARS-CoV-2 should be added to the list of human enteric pathogens.
Identifiants
pubmed: 35996551
doi: 10.1016/j.heliyon.2022.e10246
pii: S2405-8440(22)01534-1
pmc: PMC9385603
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e10246Informations de copyright
© 2022 Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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