Association between previous abortion history and risk of autism spectrum disorders among offspring: a meta-analysis.
Abortion
Autism spectrum disorders
Child
Meta-analysis
Journal
Clinical and experimental pediatrics
ISSN: 2713-4148
Titre abrégé: Clin Exp Pediatr
Pays: Korea (South)
ID NLM: 101761234
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
17
01
2022
accepted:
13
06
2022
pubmed:
24
8
2022
medline:
24
8
2022
entrez:
23
8
2022
Statut:
ppublish
Résumé
Previous studies have been showed an association between previous abortion history and risk of Autism spectrum disorders (ASD). However, there is still controversy about true effect estimate of the association. This meta-analysis aimed to evaluate the association between previous abortion history and the risk of ASD. A systematic search was performed using PubMed, Scopus, and Web of Sciences databases to identify potential studies published until December 2021. The presence of statistical heterogeneity was determined using the I2 value. In the case of substantial heterogeneity, the random-effects model meta-analysis was used to estimate the pooled relative risks. The publication bias was assessed using the Egger and Begg tests. Thirteen studies with a total of 331,779 children remained in the present meta-analysis. The estimated odds ratio of the risk of ASD associated with previous abortion history was 1.64 (95% confidence interval [CI], 1.28-2.0; I2=61.7%) in adjusted studies and 1.10 (95% CI, 1.01-1.20; I2=0.0%) in crude studies, based on the random effect model. There was moderate heterogeneity in adjusted studies. The p values for Egger and Begg regression among children with ASD were 0.393 and 0.056, respectively. This meta-analysis suggests that children born from mothers with a history of previous abortion have an increased risk of development of ASD compared to children of mothers without a history of previous abortion.
Sections du résumé
BACKGROUND
BACKGROUND
Previous studies have been showed an association between previous abortion history and risk of Autism spectrum disorders (ASD). However, there is still controversy about true effect estimate of the association.
PURPOSE
OBJECTIVE
This meta-analysis aimed to evaluate the association between previous abortion history and the risk of ASD.
METHODS
METHODS
A systematic search was performed using PubMed, Scopus, and Web of Sciences databases to identify potential studies published until December 2021. The presence of statistical heterogeneity was determined using the I2 value. In the case of substantial heterogeneity, the random-effects model meta-analysis was used to estimate the pooled relative risks. The publication bias was assessed using the Egger and Begg tests.
RESULTS
RESULTS
Thirteen studies with a total of 331,779 children remained in the present meta-analysis. The estimated odds ratio of the risk of ASD associated with previous abortion history was 1.64 (95% confidence interval [CI], 1.28-2.0; I2=61.7%) in adjusted studies and 1.10 (95% CI, 1.01-1.20; I2=0.0%) in crude studies, based on the random effect model. There was moderate heterogeneity in adjusted studies. The p values for Egger and Begg regression among children with ASD were 0.393 and 0.056, respectively.
CONCLUSION
CONCLUSIONS
This meta-analysis suggests that children born from mothers with a history of previous abortion have an increased risk of development of ASD compared to children of mothers without a history of previous abortion.
Identifiants
pubmed: 35996797
pii: cep.2022.00108
doi: 10.3345/cep.2022.00108
pmc: PMC9899555
doi:
Types de publication
Journal Article
Langues
eng
Pagination
70-75Subventions
Organisme : Hamadan University of Medical Sciences
ID : 140010218787
Références
Nutrients. 2020 Dec 29;13(1):
pubmed: 33383952
Medicine (Baltimore). 2018 Jan;97(2):e9438
pubmed: 29480832
Eur J Epidemiol. 2019 Feb;34(2):105-114
pubmed: 30291529
N Engl J Med. 1997 Jul 17;337(3):154-60
pubmed: 9219701
J Am Acad Child Adolesc Psychiatry. 2014 Oct;53(10):1074-81.e4
pubmed: 25245351
Evid Based Ment Health. 2018 Aug;21(3):95-100
pubmed: 30006442
Clin Endocrinol (Oxf). 2003 Sep;59(3):282-8
pubmed: 12919150
J Child Psychol Psychiatry. 2013 Jan;54(1):3-16
pubmed: 22963644
BMC Pediatr. 2021 Feb 1;21(1):62
pubmed: 33522911
JAMA. 2000 Apr 19;283(15):2008-12
pubmed: 10789670
Korean J Pediatr. 2019 Oct;62(10):374-379
pubmed: 31208166
Adv Exp Med Biol. 2017;978:63-90
pubmed: 28523541
Acta Psychiatr Scand. 2017 Jan;135(1):29-41
pubmed: 27858958
Dev Med Child Neurol. 2019 Jan;61(1):91-97
pubmed: 30058166
Clin Exp Pediatr. 2021 Oct;64(10):538-542
pubmed: 33539699
Cureus. 2021 Aug 9;13(8):e17016
pubmed: 34522497
J Res Health Sci. 2013 Sep 17;13(2):119-24
pubmed: 24077467
Int J Environ Res Public Health. 2020 Aug 31;17(17):
pubmed: 32878029
Hum Reprod. 2020 May 1;35(5):1211-1221
pubmed: 32340041
Clin Exp Pediatr. 2020 Jan;63(1):8-13
pubmed: 31999913
J Assist Reprod Genet. 2016 Jul;33(7):833-47
pubmed: 27169601
Compr Psychiatry. 2006 Jan-Feb;47(1):69-75
pubmed: 16324905
Autism Res. 2012 Feb;5(1):21-30
pubmed: 21972225
Brain Behav Immun. 2016 Nov;58:165-172
pubmed: 27287966
Pediatrics. 2018 Sep;142(3):
pubmed: 30076190
J Pediatr. 2012 Nov;161(5):830-6
pubmed: 22677565
J Autism Dev Disord. 2011 Jul;41(7):891-902
pubmed: 20922473
J Thyroid Res. 2013;2013:851326
pubmed: 23762776
Pediatrics. 2011 Jun;127(6):1034-42
pubmed: 21606152
J Child Psychol Psychiatry. 2018 Jul;59(7):744-751
pubmed: 29377119
Front Psychol. 2021 Sep 21;12:707500
pubmed: 34621214
J Autism Dev Disord. 2014 Jul;44(7):1546-55
pubmed: 24337796
Brain Sci. 2020 May 14;10(5):
pubmed: 32423096
Pediatrics. 2009 Aug;124(2):717-28
pubmed: 19651588
JAMA Psychiatry. 2013 May;70(5):508-15
pubmed: 23553149
Arch Pediatr Adolesc Med. 2003 Apr;157(4):397-402
pubmed: 12695238
Pediatrics. 2009 Nov;124(5):e817-25
pubmed: 19841112
Fertil Steril. 2005 Oct;84(4):980-4
pubmed: 16213853
Pediatrics. 2011 Aug;128(2):344-55
pubmed: 21746727
Neuropsychiatr Dis Treat. 2014 Jul 08;10:1267-72
pubmed: 25045270
Thyroid. 2010 Sep;20(9):989-93
pubmed: 20718684
Dev Med Child Neurol. 2021 Jul;63(7):831-838
pubmed: 33580539