Extracellular vesicles in atherothrombosis: From biomarkers and precision medicine to therapeutic targets.
atherosclerosis
extracellular vesicles
inflammation
ischemic disease
microvesicles
thrombosis
Journal
Immunological reviews
ISSN: 1600-065X
Titre abrégé: Immunol Rev
Pays: England
ID NLM: 7702118
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
pubmed:
24
8
2022
medline:
12
10
2022
entrez:
23
8
2022
Statut:
ppublish
Résumé
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of global mortality. Extracellular vesicles (EVs) are small phospholipid vesicles that convey molecular bioactive cargoes and play essential roles in intercellular communication and, hence, a multifaceted role in health and disease. The present review offers a glimpse into the current state and up-to-date concepts on EV field. It also covers their association with several cardiovascular risk factors and ischemic conditions, being subclinical atherosclerosis of utmost relevance for prevention. Interestingly, we show that EVs hold promise as prognostic and diagnostic as well as predictive markers of ASCVD in the precision medicine era. We then report on the role of EVs in atherothrombosis, disentangling the mechanisms involved in the initiation, progression, and complication of atherosclerosis and showing their direct effect in the context of arterial thrombosis. Finally, their potential use for therapeutic intervention is highlighted.
Substances chimiques
Biomarkers
0
Phospholipids
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6-19Informations de copyright
© 2022 The Authors. Immunological Reviews published by John Wiley & Sons Ltd.
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