PLGA Nanoparticles Uptake in Stem Cells from Human Exfoliated Deciduous Teeth and Oral Keratinocyte Stem Cells.
PLGA nanoparticles
human exfoliated deciduous teeth
oral keratinocyte stem cells
Journal
Journal of functional biomaterials
ISSN: 2079-4983
Titre abrégé: J Funct Biomater
Pays: Switzerland
ID NLM: 101570734
Informations de publication
Date de publication:
31 Jul 2022
31 Jul 2022
Historique:
received:
30
06
2022
revised:
26
07
2022
accepted:
27
07
2022
entrez:
23
8
2022
pubmed:
24
8
2022
medline:
24
8
2022
Statut:
epublish
Résumé
Polymeric nanoparticles have been introduced as a delivery vehicle for active compounds in a broad range of medical applications due to their biocompatibility, stability, controlled release of active compounds, and reduced toxicity. The oral route is the most used approach for delivery of biologics to the body. The homeostasis and function of oral cavity tissues are dependent on the activity of stem cells. The present work focuses, for the first time, on the interaction between two types of polymeric nanoparticles, poly (lactic-co-glycolic acid) or PLGA and PLGA/chitosan, and two stem cell populations, oral keratinocyte stem cells (OKSCs) and stem cells from human exfoliated deciduous teeth (SHEDs). The main results show that statistical significance was observed in OKSCs uptake when compared with normal keratinocytes and transit amplifying cells after 24 h of incubation with 5 and 10 µg/mL PLGA/chitosan. The CD117
Identifiants
pubmed: 35997447
pii: jfb13030109
doi: 10.3390/jfb13030109
pmc: PMC9397094
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fulbright US-Rom Commision
ID : Fulbright Senior Grant, title: Polymeric nanoparticle synthesis targeted for oral epithelial stem cells
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