International consensus recommendations for management of New Onset Refractory Status Epilepticus (NORSE) incl. Febrile Infection-Related Epilepsy Syndrome (FIRES): Statements and Supporting Evidence.
Adult
Anti-seizure medication
Delphi
Epilepsy
Immunotherapy
Ketogenic diet
Pediatric
Refractory status epilepticus
Status epilepticus
Journal
Epilepsia
ISSN: 1528-1167
Titre abrégé: Epilepsia
Pays: United States
ID NLM: 2983306R
Informations de publication
Date de publication:
23 Aug 2022
23 Aug 2022
Historique:
entrez:
23
8
2022
pubmed:
24
8
2022
medline:
24
8
2022
Statut:
aheadofprint
Résumé
To develop consensus-based recommendations for the management of adult and paediatric patients with NORSE/FIRES based on best evidence and experience. The Delphi methodology was followed. A facilitator group of 9 experts was established, who defined the scope, users and suggestions for recommendations. Following a review of the current literature, recommendation statements concerning diagnosis, treatment and research directions were generated which were then voted on a scale of 1 (strongly disagree) to 9 (strongly agree) by a panel of 48 experts in the field. Consensus that a statement was appropriate was reached if the median score was greater or equal to 7, and inappropriate if the median score was less than or equal to 3. The analysis of evidence was mapped to the results of each statement included in the Delphi survey. Overall, 85 recommendation statements achieved consensus. The recommendations are divided into five sections: 1) disease characteristics, 2) diagnostic testing and sampling, 3) acute treatment, 4) treatment in the post-acute phase, and 5) research, registries and future directions in NORSE/FIRES. The detailed results and discussion of all 85 statements are outlined herein. A corresponding summary of findings and practical flowsheets are presented in a companion article. This detailed analysis offers insight into the supporting evidence and the current gaps in the literature that are associated with expert consensus statements related to NORSE/FIRES. The recommendations generated by this consensus can be used as a guide for the diagnosis, evaluation, and management of patients with NORSE/FIRES, and for planning of future research.
Identifiants
pubmed: 35997591
doi: 10.1111/epi.17397
pmc: PMC9828002
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM130447
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Investigateurs
Stephane Auvin
(S)
Andreas van Baalen
(A)
Ettore Beghi
(E)
Susanne M Bensler
(SM)
Peter Bergin
(P)
Tom Bleck
(T)
Andreas Brunklaus
(A)
Roberto H Caraballo
(RH)
Mackenzie Cervenka
(M)
Daniel Costello
(D)
Frank Drislane
(F)
Raquel Farias-Moeller
(R)
William Gallantine
(W)
Emily Gilmore
(E)
Teneille Gofton
(T)
Maria Angeles Perez Jimenez
(M)
Sara Hocker
(S)
Marios Kaliakatsos
(M)
Marissa Kellogg
(M)
Jong Woo Lee
(J)
Tobias Loddenkemper
(T)
Stefano Meletti
(S)
Masashi Mizugushi
(M)
Eyal Muscal
(E)
James J Riviello
(JJ)
Eric S Rosenthal
(ES)
Andrea O Rossetti
(AO)
Stefan Ruegg
(S)
Rana Said
(R)
Claudine Sculier
(C)
Sarah Schmitt
(S)
Stephan Schuele
(S)
Coral Stredny
(C)
Eugen Trinka
(E)
Mark Wainwright
(M)
Stephen VanHaerents
(S)
Elisabeth Wells
(E)
Elaine Wirrell
(E)
Sameer M Zuberi
(SM)
Informations de copyright
This article is protected by copyright. All rights reserved.
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