Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people.
genome-wide association study
language
meta-analysis
reading
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
30 08 2022
30 08 2022
Historique:
entrez:
23
8
2022
pubmed:
24
8
2022
medline:
26
8
2022
Statut:
ppublish
Résumé
The use of spoken and written language is a fundamental human capacity. Individual differences in reading- and language-related skills are influenced by genetic variation, with twin-based heritability estimates of 30 to 80% depending on the trait. The genetic architecture is complex, heterogeneous, and multifactorial, but investigations of contributions of single-nucleotide polymorphisms (SNPs) were thus far underpowered. We present a multicohort genome-wide association study (GWAS) of five traits assessed individually using psychometric measures (word reading, nonword reading, spelling, phoneme awareness, and nonword repetition) in samples of 13,633 to 33,959 participants aged 5 to 26 y. We identified genome-wide significant association with word reading (rs11208009,
Identifiants
pubmed: 35998220
doi: 10.1073/pnas.2202764119
pmc: PMC9436320
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2202764119Subventions
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Pays : United States
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
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Organisme : Medical Research Council
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Organisme : Medical Research Council
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Pays : United States
Organisme : HHS | National Institutes of Health (NIH)
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Organisme : NIDA NIH HHS
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Pays : United States
Organisme : HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
ID : P50 HD 27802
Organisme : NICHD NIH HHS
ID : P50 HD027802
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Organisme : NIDA NIH HHS
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Organisme : CIHR
ID : MOP-133440
Pays : Canada
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ID : R01 DC014489
Pays : United States
Organisme : Wellcome Trust
ID : 082036/B/07/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19009
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : RC2 MH089995
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA051018
Pays : United States
Organisme : CIHR
ID : MOP-82893
Pays : Canada
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ID : K99 HD094902
Pays : United States
Organisme : Wellcome Trust
ID : 075491/Z/04
Pays : United Kingdom
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041093
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC016977
Pays : United States
Organisme : HHS | NIH | National Institute of Mental Health (NIMH)
ID : 1U01MH109514-01
Organisme : EPA
ID : EP-C-15-001
Pays : United States
Organisme : Wellcome Trust
ID : 217065/Z/19/Z
Pays : United Kingdom
Organisme : NIDA NIH HHS
ID : U24 DA041123
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041134
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041022
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG046938
Pays : United States
Organisme : NIMH NIH HHS
ID : RC2 MH089924
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_15018
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH058799
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041156
Pays : United States
Organisme : Wellcome Trust
ID : 076566/Z/05/Z
Pays : United Kingdom
Organisme : NIDA NIH HHS
ID : U01 DA050987
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA051016
Pays : United States
Organisme : Wellcome Trust
ID : 204821/Z/16/Z
Pays : United Kingdom
Organisme : NIDA NIH HHS
ID : U01 DA041025
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Organisme : NIDA NIH HHS
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ID : U01 DA041089
Pays : United States
Organisme : Medical Research Council
ID : MR/M021475/1
Pays : United Kingdom
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ID : U01 DA050988
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Organisme : NIMH NIH HHS
ID : U24 MH068457
Pays : United States
Organisme : Wellcome Trust
ID : 105621/Z/14/Z
Pays : United Kingdom
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Organisme : NIDA NIH HHS
ID : U01 DA041028
Pays : United States
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ID : U01 DA041048
Pays : United States
Organisme : Medical Research Council
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Pays : United Kingdom
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Organisme : Medical Research Council
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Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIDA NIH HHS
ID : U01 DA041174
Pays : United States
Organisme : Wellcome Trust (WT)
ID : WT082032MA
Organisme : Wellcome Trust
ID : 076566
Pays : United Kingdom
Organisme : NIDA NIH HHS
ID : RC2 DA029475
Pays : United States
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