Farnesoid X receptor regulates lung macrophage activation and injury following nitrogen mustard exposure.
FXR
Lung toxicity
Macrophages
Mustard vesicants
Oxidative stress
Journal
Toxicology and applied pharmacology
ISSN: 1096-0333
Titre abrégé: Toxicol Appl Pharmacol
Pays: United States
ID NLM: 0416575
Informations de publication
Date de publication:
01 11 2022
01 11 2022
Historique:
received:
30
06
2022
revised:
14
08
2022
accepted:
17
08
2022
pubmed:
24
8
2022
medline:
14
10
2022
entrez:
23
8
2022
Statut:
ppublish
Résumé
Nitrogen mustard (NM) is a cytotoxic vesicant known to cause acute lung injury which progresses to fibrosis; this is associated with a sequential accumulation of pro- and anti-inflammatory macrophages in the lung which have been implicated in NM toxicity. Farnesoid X receptor (FXR) is a nuclear receptor involved in regulating lipid homeostasis and inflammation. In these studies, we analyzed the role of FXR in inflammatory macrophage activation, lung injury and oxidative stress following NM exposure. Wild-type (WT) and FXR
Identifiants
pubmed: 35998709
pii: S0041-008X(22)00353-2
doi: 10.1016/j.taap.2022.116208
pmc: PMC9960619
mid: NIHMS1871223
pii:
doi:
Substances chimiques
Irritants
0
Lipids
0
Mechlorethamine
50D9XSG0VR
Heme Oxygenase-1
EC 1.14.14.18
Cyclooxygenase 2
EC 1.14.99.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
116208Subventions
Organisme : NIEHS NIH HHS
ID : T32 ES007148
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES005022
Pays : United States
Organisme : NIEHS NIH HHS
ID : F32 ES030984
Pays : United States
Organisme : NIAMS NIH HHS
ID : U54 AR055073
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM135258
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES004738
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES033698
Pays : United States
Organisme : NIEHS NIH HHS
ID : R25 ES020721
Pays : United States
Organisme : NIH HHS
ID : S10 OD026876
Pays : United States
Informations de copyright
Copyright © 2022. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Toxicol Sci. 2015 Nov;148(1):71-88
pubmed: 26243812
Eur Respir J. 2015 Nov;46(5):1451-60
pubmed: 26113683
Respirology. 2016 Aug;21(6):1075-80
pubmed: 27185272
Front Genet. 2014 Dec 10;5:422
pubmed: 25540650
Annu Rev Pharmacol Toxicol. 2011;51:267-88
pubmed: 20887196
Shock. 2016 Aug;46(2):122-31
pubmed: 26954942
Toxicol Appl Pharmacol. 2020 Jan 15;387:114798
pubmed: 31678244
Crit Care Med. 2002 Aug;30(8):1679-85
pubmed: 12163776
Biochim Biophys Acta. 2006 Dec;1761(12):1401-9
pubmed: 17110163
Nat Commun. 2017 Oct 11;8(1):851
pubmed: 29021573
BMC Womens Health. 2011 Jun 03;11:24
pubmed: 21639909
Front Immunol. 2018 Aug 13;9:1853
pubmed: 30150987
Toxicol Sci. 2018 Nov 1;166(1):108-122
pubmed: 30060251
Toxicol Sci. 2019 Dec 1;172(2):344-358
pubmed: 31428777
Biochim Biophys Acta. 2013 Jul;1832(7):989-97
pubmed: 23246690
Front Immunol. 2018 May 28;9:1175
pubmed: 29892301
Nat Immunol. 2015 Jan;16(1):36-44
pubmed: 25521683
Am J Respir Crit Care Med. 1996 May;153(5):1548-52
pubmed: 8630600
Br J Pharmacol. 2011 Dec;164(8):1929-38
pubmed: 21564085
Mol Pharmacol. 2018 Aug;94(2):802-811
pubmed: 29743187
Am J Respir Cell Mol Biol. 2015 Jul;53(1):74-86
pubmed: 25409201
J Endocrinol Invest. 2019 Mar;42(3):283-294
pubmed: 29923060
Int J Mol Sci. 2021 Jan 03;22(1):
pubmed: 33401552
Can Respir J. 2020 Nov 26;2020:9137251
pubmed: 33294085
Curr Pharmacol Rep. 2017 Apr;3(2):92-100
pubmed: 28983452
Am J Pathol. 2019 May;189(5):999-1014
pubmed: 30794808
PLoS One. 2014 Feb 03;9(2):e88011
pubmed: 24498423
J Steroid Biochem Mol Biol. 2017 Jan;165(Pt B):277-292
pubmed: 27425465
Eur Respir J. 2021 Jan 21;57(1):
pubmed: 32764118
Mol Med. 2020 Nov 5;26(1):100
pubmed: 33153429
Am J Physiol Lung Cell Mol Physiol. 2014 Sep 1;307(5):L407-18
pubmed: 24993131
J Toxicol Environ Health B Crit Rev. 1999 Jan-Mar;2(1):31-86
pubmed: 10081525
J Exp Med. 2011 Jun 6;208(6):1189-201
pubmed: 21555486
Int J Mol Sci. 2019 Sep 05;20(18):
pubmed: 31491899
Am J Respir Cell Mol Biol. 2016 Mar;54(3):436-46
pubmed: 26273949
Nat Rev Immunol. 2014 Feb;14(2):81-93
pubmed: 24445666
Arch Pathol Lab Med. 2011 Jun;135(6):780-8
pubmed: 21631273
J Steroid Biochem Mol Biol. 2017 Apr;168:26-37
pubmed: 28115235
Biomed Res Int. 2016;2016:9283204
pubmed: 27340672
J Immunol. 2006 Jul 1;177(1):621-30
pubmed: 16785560
Curr Opin Pulm Med. 2004 Mar;10(2):98-103
pubmed: 15021178
Front Immunol. 2018 Jan 05;8:1932
pubmed: 29354135
Oncogene. 2008 Aug 7;27(34):4712-23
pubmed: 18408758
Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11193-8
pubmed: 21690378
Mucosal Immunol. 2022 Feb;15(2):223-234
pubmed: 35017701
Toxicol Sci. 2019 Apr 1;168(2):287-301
pubmed: 30590802
Am J Physiol Cell Physiol. 2018 Apr 1;314(4):C449-C455
pubmed: 29351405
J Virol. 2014 May;88(9):4711-20
pubmed: 24522912
Ann N Y Acad Sci. 2016 Jun;1374(1):168-75
pubmed: 27351588
J Biol Chem. 2018 Jun 22;293(25):9892-9909
pubmed: 29618517
Cell Rep. 2018 Feb 13;22(7):1810-1823
pubmed: 29444433
Int Immunopharmacol. 2019 Jan;66:177-184
pubmed: 30468885
Thorax. 2015 Dec;70(12):1189-96
pubmed: 26286722
Immunity. 2016 Mar 15;44(3):450-462
pubmed: 26982353
Inflamm Res. 2015 Jan;64(1):9-20
pubmed: 25376338
Front Immunol. 2021 Dec 10;12:781815
pubmed: 34956210
Exp Mol Pathol. 2014 Aug;97(1):89-98
pubmed: 24886962
Shock. 2014 Mar;41(3):208-13
pubmed: 24220282
Toxicol Sci. 2020 Oct 1;177(2):441-453
pubmed: 32984886
J Clin Invest. 2019 Oct 1;129(10):4290-4304
pubmed: 31483291