Hyaluronan synthase 3 is protective after cardiac ischemia-reperfusion by preserving the T cell response.
Extracellular matrix
Hyaluronan synthase 3
Myocardial infarction
T cells
Journal
Matrix biology : journal of the International Society for Matrix Biology
ISSN: 1569-1802
Titre abrégé: Matrix Biol
Pays: Netherlands
ID NLM: 9432592
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
28
03
2022
revised:
02
08
2022
accepted:
18
08
2022
pubmed:
24
8
2022
medline:
4
10
2022
entrez:
23
8
2022
Statut:
ppublish
Résumé
Dysregulated extracellular matrix (ECM) is a hallmark of adverse cardiac remodeling after myocardial infarction (MI). Previous work from our laboratory suggests that synthesis of the major ECM component hyaluronan (HA) may be beneficial for post-infarct healing. Here, we aimed to investigate the mechanisms of hyaluronan synthase 3 (HAS3) in cardiac healing after MI. Mice with genetic deletion of Has3 (Has3 KO) and wildtype mice (WT) underwent 45 min of ischemia with subsequent reperfusion (I/R), followed by monitoring of heart function and analysis of tissue remodeling for up to three weeks. Has3 KO mice exhibited impaired cardiac function as evidenced by a reduced ejection fraction. Accordingly, Has3 deficiency also resulted in an increased scar size. Cardiac fibroblast activation and CD68
Identifiants
pubmed: 35998871
pii: S0945-053X(22)00102-0
doi: 10.1016/j.matbio.2022.08.008
pii:
doi:
Substances chimiques
Annexin A5
0
Isoenzymes
0
Hyaluronic Acid
9004-61-9
HAS3 protein, human
EC 2.4.1.212
Has3 protein, mouse
EC 2.4.1.212
Hyaluronan Synthases
EC 2.4.1.212
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
116-131Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Disclosures The authors have no disclosures.