The role of opportunistic quantitative computed tomography in the evaluation of bone disease and risk of fracture in thalassemia major.
dual-energy x-ray absorptiometry
fractures
osteoporosis
thalassemia
x-ray computed tomography
Journal
European journal of haematology
ISSN: 1600-0609
Titre abrégé: Eur J Haematol
Pays: England
ID NLM: 8703985
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
revised:
12
08
2022
received:
05
07
2022
accepted:
18
08
2022
pubmed:
25
8
2022
medline:
15
11
2022
entrez:
24
8
2022
Statut:
ppublish
Résumé
Dual-energy X-ray absorptiometry (DXA) remains the cornerstone for osteoporosis evaluation in Thalassemia major. However, several drawbacks have been observed in this unique setting. We sought to determine the correlation between quantitative CT (QCT) and DXA-derived parameters; secondarily, we aimed to investigate the role of the two techniques in predicting the risk of fracture. We retrospectively included patients with β-thalassemia major who had undergone both lumbar and femoral DXA examinations, and CT scans including the lumbar spine, performed for disparate diagnostic issues, within 4 months from the DXA. CT data were examined employing a phantom-less QCT method for bone mineral density (BMD) assessment. We also retrieved any spontaneous or fragility fractures occurring from 1 year before up to 5 years after the date of DXA scans. The 43 patients were included. QCT measures were significantly higher than those determined by DXA. The gap between QCT and DXA values was strongly associated with patient age. The most powerful predictive variable for risk of fracture was the ACR classification based on volumetric BMD obtained by QCT. DXA provided more negative measures than those determined by QCT. However, QCT seemed to evaluate thalassaemic osteopathy better than DXA, since volumetric BMD was a stronger predictor of fracture.
Identifiants
pubmed: 36000276
doi: 10.1111/ejh.13847
pmc: PMC9826074
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
648-655Informations de copyright
© 2022 The Authors. European Journal of Haematology published by John Wiley & Sons Ltd.
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