1,3-Dichloro-2-propanol-Induced Renal Tubular Cell Necroptosis through the ROS/RIPK3/MLKL Pathway.

Animals Kidney / metabolism Mice Mice, Inbred C57BL NF-E2-Related Factor 2 / genetics Necroptosis Protein Kinases / genetics Reactive Oxygen Species / metabolism Receptor-Interacting Protein Serine-Threonine Kinases / genetics alpha-Chlorohydrin / analogs & derivatives
1,3-dichloro-2-propanol Nrf2 ROS mitophagy necroptosis renal tubular cells

Journal

Journal of agricultural and food chemistry
ISSN: 1520-5118
Titre abrégé: J Agric Food Chem
Pays: United States
ID NLM: 0374755

Informations de publication

Date de publication:
07 Sep 2022
Historique:
pubmed: 25 8 2022
medline: 9 9 2022
entrez: 24 8 2022
Statut: ppublish

Résumé

1,3-Dichloro-2-propanol (1,3-DCP), as a food pollutant, exists in a variety of foods. Studies have shown that it has nephrotoxicity. In the study, we found that 1,3-DCP caused renal injury with necroptosis in C57BL/6J mice. The mechanism of 1,3-DCP-caused nephrotoxicity was further explored in NRK-52E cells

Identifiants

DOI: 10.1021/acs.jafc.2c02619 PMID: 36000575
pubmed: 36000575
doi: 10.1021/acs.jafc.2c02619
doi:

Substances chimiques

NF-E2-Related Factor 2 0
Reactive Oxygen Species 0
1,3-dichloro-2-propanol 0F4P2VQC07
alpha-Chlorohydrin 96-24-2
MLKL protein, mouse EC 2.7.-
Protein Kinases EC 2.7.-
Receptor-Interacting Protein Serine-Threonine Kinases EC 2.7.11.1
Ripk3 protein, mouse EC 2.7.11.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

10847-10857

Auteurs

Yong Fan (Y)

College of Food Science and Engineering, Jilin University, Changchun, Jilin 130062, People's Republic of China.

Jing Lu (J)

College of Food Science and Engineering, Jilin University, Changchun, Jilin 130062, People's Republic of China.
Key Laboratory of Zoonosis, Ministry of Education College of Veterinary Medicine, Jilin University, Changchun, Jilin 130062, People's Republic of China.

Zelin Yu (Z)

College of Food Science and Engineering, Jilin University, Changchun, Jilin 130062, People's Republic of China.

Xiao Qu (X)

College of Food Science and Engineering, Jilin University, Changchun, Jilin 130062, People's Republic of China.

Shuang Guan (S)

College of Food Science and Engineering, Jilin University, Changchun, Jilin 130062, People's Republic of China.
Key Laboratory of Zoonosis, Ministry of Education College of Veterinary Medicine, Jilin University, Changchun, Jilin 130062, People's Republic of China.
ORCID: 0000-0003-4948-167X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › 1,3-Dichloro-2-propanol-Induced Renal Tubular...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › 1,3-Dichloro-2-propanol-Induced Renal Tubular...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › 1,3-Dichloro-2-propanol-Induced Renal Tubular...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › 1,3-Dichloro-2-propanol-Induced Renal Tubular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteur-2 apparenté à NF-E2 › 1,3-Dichloro-2-propanol-Induced Renal Tubular...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Nécroptose › 1,3-Dichloro-2-propanol-Induced Renal Tubular...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › Protein kinases › 1,3-Dichloro-2-propanol-Induced Renal Tubular...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › 1,3-Dichloro-2-propanol-Induced Renal Tubular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Receptor-Interacting Protein Serine-Threonine Kinases › 1,3-Dichloro-2-propanol-Induced Renal Tubular...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Glycols › Propylène glycols › alpha-Chlorohydrine › 1,3-Dichloro-2-propanol-Induced Renal Tubular...