Atypical Alzheimer's disease phenotypes with normal or borderline PET biomarker profiles.
Abnormal Aβ-PET uptake
Abnormal tau-PET uptake
Logopenic progressive aphasia
Posterior cortical atrophy
Journal
Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
24
05
2022
accepted:
07
08
2022
revised:
05
08
2022
pubmed:
25
8
2022
medline:
2
11
2022
entrez:
24
8
2022
Statut:
ppublish
Résumé
Posterior cortical atrophy (PCA) and logopenic progressive aphasia (LPA) are clinical syndromes that commonly have underlying Alzheimer's disease (AD), although non-AD pathologies have also been reported. PET imaging allows for identification of beta-amyloid (Aβ) and tau in AD, so we aimed to assess these in a large cohort to identify patients that do not have evidence for biomarker-defined AD. Eight-one patients, 47 PCA and 34 LPA, underwent extensive neurological and neuropsychological testing, [
Identifiants
pubmed: 36001141
doi: 10.1007/s00415-022-11330-5
pii: 10.1007/s00415-022-11330-5
pmc: PMC9707302
mid: NIHMS1850221
doi:
Substances chimiques
tau Proteins
0
Amyloid beta-Peptides
0
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6613-6626Subventions
Organisme : NIA NIH HHS
ID : R01 AG050603
Pays : United States
Organisme : Alzheimer's Association
ID : NIRG-12-242215
Pays : United States
Organisme : NIH HHS
ID : R01-AG50603
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
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