Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD.
Journal
Seminars in liver disease
ISSN: 1098-8971
Titre abrégé: Semin Liver Dis
Pays: United States
ID NLM: 8110297
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
entrez:
24
8
2022
pubmed:
25
8
2022
medline:
27
8
2022
Statut:
ppublish
Résumé
Nonalcoholic liver disease is a component of metabolic syndrome associated with obesity, insulin resistance, and hyperlipidemia. Excessive alcohol consumption may accelerate the progression of steatosis, steatohepatitis, and fibrosis. While simple steatosis is considered a benign condition, nonalcoholic steatohepatitis with inflammation and fibrosis may progress to cirrhosis, liver failure, and hepatocellular cancer. Studies in rodent experimental models and primary cell cultures have demonstrated several common cellular and molecular mechanisms in the pathogenesis and regression of liver fibrosis. Chronic injury and death of hepatocytes cause the recruitment of myeloid cells, secretion of inflammatory and fibrogenic cytokines, and activation of myofibroblasts, resulting in liver fibrosis. In this review, we discuss the role of metabolically injured hepatocytes in the pathogenesis of nonalcoholic steatohepatitis and alcohol-associated liver disease. Specifically, the role of chemokine production and de novo lipogenesis in the development of steatotic hepatocytes and the pathways of steatosis regulation are discussed.
Identifiants
pubmed: 36001995
doi: 10.1055/s-0042-1755316
pmc: PMC9662188
mid: NIHMS1844224
doi:
Types de publication
Journal Article
Review
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
233-249Subventions
Organisme : NIAAA NIH HHS
ID : U01 AA018663
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001442
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES010337
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK120515
Pays : United States
Organisme : NIDDK NIH HHS
ID : F32 DK009920
Pays : United States
Organisme : NIAAA NIH HHS
ID : P50 AA011999
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL147835
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK121378
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA026939
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK106419
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA029019
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA024726
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK091183
Pays : United States
Organisme : NIAAA NIH HHS
ID : R37 AA020703
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK111866
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK099205
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA028550
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK124318
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061734
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA022614
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK101737
Pays : United States
Organisme : NIDDK NIH HHS
ID : R44 DK115242
Pays : United States
Informations de copyright
Thieme. All rights reserved.
Déclaration de conflit d'intérêts
R.L. serves as a consultant for Aardvark Therapeutics, Altimmune, Anylam/Regeneron, Amgen, Arrowhead Pharmaceuticals, AstraZeneca, Bristol-Myer Squibb, CohBar, Eli Lilly, Galmed, Gilead, Glympse bio, Hightide, Inipharm, Intercept, Inventiva, Ionis, Janssen Inc., Madrigal, Metacrine, Inc., NGM Biopharmaceuticals, Novartis, Novo Nordisk, Merck, Pfizer, Sagimet, Theratechnologies, 89 bio, and Viking Therapeutics. In addition, his institution has received grant support from Allergan, Astrazeneca, Boehringer-Ingelheim, Bristol-Myers Squibb, Eli Lilly, Galectin Therapeutics, Galmed Pharmaceuticals, Genfit, Gilead, Intercept, Inventiva, Janssen, Madrigal Pharmaceuticals, Merck, NGM Biopharmaceuticals, Pfizer, and Sonic Incytes. He is also cofounder of Liponexus, Inc. B.S. has been consulting for Ferring Research Institute, Gelesis, HOST Therabiomics, Intercept Pharmaceuticals, Mabwell Therapeutics, Patara Pharmaceuticals, and Takeda. B.S. is founder of Nterica Bio. UC San Diego has filed several patents with B.S. as inventor related to this work. B.S.'s institution UC San Diego has received research support from Axial Biotherapeutics, BiomX, CymaBay Therapeutics, NGM Biopharmaceuticals, Prodigy Biotech, and Synlogic Operating Company.
Références
J Clin Invest. 2009 May;119(5):1201-15
pubmed: 19363290
Alcohol Clin Exp Res. 2011 May;35(5):787-93
pubmed: 21284667
Gastroenterology. 2008 Feb;134(2):568-76
pubmed: 18082745
Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):913-7
pubmed: 8302866
Mol Cell Biol. 1998 Dec;18(12):7499-509
pubmed: 9819435
Nat Rev Gastroenterol Hepatol. 2021 Mar;18(3):151-166
pubmed: 33128017
Biomedicines. 2020 Aug 01;8(8):
pubmed: 32752275
J Mol Med (Berl). 2020 Jul;98(7):1021-1034
pubmed: 32556367
Mol Cell. 2018 Jan 18;69(2):238-252.e7
pubmed: 29351844
J Cell Biol. 2009 Aug 10;186(3):323-31
pubmed: 19651891
Cell Struct Funct. 2008;33(1):75-89
pubmed: 18360008
Gastroenterology. 2011 Nov;141(5):1572-85
pubmed: 21920463
Sci Signal. 2014 Jun 10;7(329):ra54
pubmed: 24917591
Curr Drug Targets. 2015;16(12):1315-23
pubmed: 26028039
Mol Cell Biol. 2004 Sep;24(18):8288-300
pubmed: 15340088
Nat Cell Biol. 2005 Aug;7(8):766-72
pubmed: 16056268
Cell Metab. 2020 May 5;31(5):969-986.e7
pubmed: 32259482
Science. 2006 Jul 7;313(5783):104-7
pubmed: 16825573
Nature. 2017 Nov 16;551(7680):340-345
pubmed: 29144460
J Biol Chem. 2012 Jun 8;287(24):20755-68
pubmed: 22500017
J Hepatol. 2020 May;72(5):946-959
pubmed: 31899206
J Hepatol. 2003;38 Suppl 1:S38-53
pubmed: 12591185
Hepatology. 2004 May;39(5):1332-42
pubmed: 15122762
Ann N Y Acad Sci. 2007 Oct;1113:58-71
pubmed: 17483206
N Engl J Med. 2009 Jun 25;360(26):2758-69
pubmed: 19553649
Immunity. 2007 Oct;27(4):647-59
pubmed: 17919941
Cell. 1996 Jun 28;85(7):1037-46
pubmed: 8674110
J Biol Chem. 2008 Apr 11;283(15):10048-57
pubmed: 18238778
Mol Metab. 2021 Jun;48:101210
pubmed: 33722690
J Hepatol. 2018 Oct;69(4):927-947
pubmed: 29940269
Mol Cell Biol. 2001 Apr;21(8):2779-89
pubmed: 11283257
J Gastroenterol Hepatol. 2013 Aug;28 Suppl 1:56-60
pubmed: 23855297
Hepatol Commun. 2019 Jul 15;3(9):1191-1204
pubmed: 31497741
Sci Rep. 2017 May 8;7(1):1529
pubmed: 28484247
J Biol Chem. 2008 Sep 12;283(37):25638-25649
pubmed: 18635549
Cell Mol Gastroenterol Hepatol. 2015 Nov 1;1(6):646-663.e4
pubmed: 26783552
Hepatology. 2005 Jun;41(6):1313-21
pubmed: 15915461
Annu Rev Biochem. 2018 Jun 20;87:783-807
pubmed: 28841344
Gastroenterology. 2000 Jun;118(6):1149-56
pubmed: 10833490
J Hepatol. 2019 Feb;70(2):249-259
pubmed: 30658726
Gut. 2020 Apr;69(4):764-780
pubmed: 31879281
Arch Biochem Biophys. 2002 Jan 15;397(2):139-48
pubmed: 11795864
In Vivo. 2007 Mar-Apr;21(2):215-26
pubmed: 17436569
Mol Cell. 2014 Feb 20;53(4):562-576
pubmed: 24508390
Genes Dev. 2000 Jan 15;14(2):152-7
pubmed: 10652269
Hepatol Commun. 2019 Jul 23;3(9):1221-1234
pubmed: 31497743
Nat Rev Gastroenterol Hepatol. 2021 Apr;18(4):223-238
pubmed: 33349658
Diabetes. 2016 Jul;65(7):1904-15
pubmed: 27207533
Science. 2012 Nov 9;338(6108):818-22
pubmed: 23042294
Hepatology. 2015 Dec;62(6):1723-30
pubmed: 26274335
Front Mol Biosci. 2019 Mar 12;6:11
pubmed: 30931312
Front Immunol. 2020 Jan 10;10:2993
pubmed: 31998297
Mol Cell. 2002 Aug;10(2):237-45
pubmed: 12191470
Cell Metab. 2016 Dec 13;24(6):848-862
pubmed: 28068223
Mol Cell Biol. 2003 Nov;23(21):7448-59
pubmed: 14559994
Biochem J. 2011 Sep 1;438(2):283-9
pubmed: 21644928
Gastroenterology. 2020 May;158(6):1728-1744.e14
pubmed: 31982409
Cell Metab. 2012 Oct 3;16(4):487-99
pubmed: 23040070
Biochem Biophys Res Commun. 1970 Aug 24;40(4):858-65
pubmed: 4395603
Hepatology. 2016 Mar;63(3):731-44
pubmed: 26406121
Immunity. 2000 Nov;13(5):715-25
pubmed: 11114383
J Anim Physiol Anim Nutr (Berl). 2008 Jun;92(3):272-83
pubmed: 18477307
Mol Cell. 1998 Oct;2(4):505-14
pubmed: 9809072
Dev Cell. 2007 Sep;13(3):351-64
pubmed: 17765679
Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16184-9
pubmed: 22927400
J Hepatol. 2009 Apr;50(4):789-96
pubmed: 19231010
J Biol Chem. 2001 Sep 28;276(39):36431-7
pubmed: 11477106
Genes Dev. 1996 Nov 15;10(22):2903-11
pubmed: 8918891
Cell. 2008 Jan 11;132(1):89-100
pubmed: 18191223
J Biol Chem. 2013 Aug 30;288(35):25350-25361
pubmed: 23888053
Cell Chem Biol. 2017 Feb 16;24(2):207-217
pubmed: 28132894
Am J Physiol Endocrinol Metab. 2005 Jun;288(6):E1195-205
pubmed: 15644454
Cell Mol Life Sci. 2009 Sep;66(17):2835-50
pubmed: 19468685
J Clin Invest. 1996 Oct 1;98(7):1575-84
pubmed: 8833906
Expert Rev Mol Med. 2011 Feb 03;13:e4
pubmed: 21288373
Biochem Biophys Res Commun. 1995 Aug 4;213(1):154-60
pubmed: 7639730
Cell Metab. 2006 Jan;3(1):15-24
pubmed: 16399501
Gastroenterology. 2007 May;132(5):2059-62
pubmed: 17484899
Biomedicines. 2018 Nov 12;6(4):
pubmed: 30424581
Clin Sci (Lond). 2009 Sep 28;118(1):19-29
pubmed: 19780718
Cell. 2001 Dec 28;107(7):881-91
pubmed: 11779464
Toxicol Sci. 2014 Jan;137(1):26-35
pubmed: 24097666
Mol Cell Biol. 2014 May;34(10):1839-49
pubmed: 24636989
Cell Metab. 2011 May 4;13(5):540-9
pubmed: 21531336
Am J Pathol. 2009 May;174(5):1776-85
pubmed: 19349371
Cell. 2006 Jan 13;124(1):35-46
pubmed: 16413480
Cell Metab. 2012 Oct 3;16(4):473-86
pubmed: 23040069
Elife. 2017 Feb 28;6:
pubmed: 28244871
Mediators Inflamm. 2009;2009:831670
pubmed: 19753129
Mol Cell. 2000 Nov;6(5):1099-108
pubmed: 11106749
Biochem J. 2002 Sep 1;366(Pt 2):585-94
pubmed: 12014989
Cell. 1997 May 2;89(3):331-40
pubmed: 9150132
World J Gastroenterol. 2014 Nov 14;20(42):15539-48
pubmed: 25400438
Gastroenterology. 2020 May;158(7):1948-1966.e1
pubmed: 32061597
Redox Biol. 2015 Dec;6:565-577
pubmed: 26496488
Cell Rep. 2013 Apr 25;3(4):1279-92
pubmed: 23583182
Hepatology. 2010 Jan;51(1):307-28
pubmed: 20034030
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5123-8
pubmed: 10805775
Annu Rev Nutr. 2000;20:169-93
pubmed: 10940331
Semin Immunol. 2016 Oct;28(5):417-424
pubmed: 27771140
J Biol Chem. 2017 Feb 17;292(7):3016-3028
pubmed: 28003358
Nat Commun. 2019 Mar 22;10(1):1326
pubmed: 30902980
J Biol Chem. 1999 Feb 5;274(6):3453-60
pubmed: 9920890
J Biol Chem. 2000 Aug 11;275(32):24333-40
pubmed: 10811639
Annu Rev Genet. 2007;41:401-27
pubmed: 17666007
EMBO J. 2011 Apr 6;30(7):1357-75
pubmed: 21407177
Hepatology. 2011 Jan;53(1):96-105
pubmed: 21254165
Dev Cell. 2007 Sep;13(3):365-76
pubmed: 17765680
Trends Endocrinol Metab. 2013 Nov;24(11):537-45
pubmed: 23827477
Clin Liver Dis. 2012 Nov;16(4):667-85
pubmed: 23101976
Cell. 1993 Nov 19;75(4):717-28
pubmed: 7902213
Trends Mol Med. 2019 Jun;25(6):538-550
pubmed: 31078432
Toxicology. 2011 Mar 28;282(1-2):39-46
pubmed: 21251946
Biochim Biophys Acta Mol Basis Dis. 2020 Oct 1;1866(10):165857
pubmed: 32512191
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3441-6
pubmed: 20133650
Hepatology. 2003 Nov;38(5):1188-98
pubmed: 14578857
J Biol Chem. 1997 Feb 7;272(6):3125-8
pubmed: 9081984
Cell Metab. 2008 Feb;7(2):95-6
pubmed: 18249166
J Clin Invest. 2002 May;109(9):1125-31
pubmed: 11994399
J Biol Chem. 2009 Mar 20;284(12):7518-32
pubmed: 19158095
Science. 2011 Nov 25;334(6059):1081-6
pubmed: 22116877
Mol Cell Biol. 2004 Feb;24(3):1365-77
pubmed: 14729979
Am J Physiol Gastrointest Liver Physiol. 2012 Jul;303(1):G9-11
pubmed: 22556144
Genes Dev. 2000 Nov 15;14(22):2819-30
pubmed: 11090130
Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12753-8
pubmed: 12242332
Gut Liver. 2012 Apr;6(2):149-71
pubmed: 22570745
Nature. 1992 Jan 2;355(6355):33-45
pubmed: 1731198
Oncotarget. 2017 Jun 28;8(38):63370-63381
pubmed: 28968997
Int J Mol Med. 2008 Apr;21(4):507-11
pubmed: 18360697
Nat Rev Endocrinol. 2017 Dec;13(12):710-730
pubmed: 28849786
BMC Endocr Disord. 2022 Mar 14;22(1):63
pubmed: 35287643
Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1764-8
pubmed: 7878056
Cell. 2011 Aug 5;146(3):408-20
pubmed: 21816276
Exp Mol Pathol. 2006 Feb;80(1):97-108
pubmed: 16332368
J Clin Invest. 2005 Feb;115(2):268-81
pubmed: 15690081
J Am Heart Assoc. 2013 Apr 05;2(2):e000093
pubmed: 23563994
Biochem Res Int. 2012;2012:841362
pubmed: 22195283
EMBO J. 2004 Feb 25;23(4):950-8
pubmed: 14765107
J Biol Chem. 2004 Jun 18;279(25):25935-8
pubmed: 15070890
J Cell Mol Med. 2021 Feb;25(3):1359-1370
pubmed: 33398919
J Exp Med. 2012 Feb 13;209(2):307-18
pubmed: 22291093
Biomedicines. 2021 Feb 05;9(2):
pubmed: 33562589
Nat Rev Gastroenterol Hepatol. 2013 Nov;10(11):686-90
pubmed: 24042449
Nature. 1999 Jan 21;397(6716):271-4
pubmed: 9930704
J Biol Chem. 2001 Feb 9;276(6):4365-72
pubmed: 11085986
J Cell Biol. 2001 May 28;153(5):1011-22
pubmed: 11381086
Sci Rep. 2017 Jun 16;7(1):3710
pubmed: 28623272
Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):E3297-305
pubmed: 25074909
J Biol Chem. 2004 Mar 19;279(12):11392-401
pubmed: 14702344
EMBO J. 1996 Mar 1;15(5):1012-20
pubmed: 8605870
Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16314-9
pubmed: 18852460
J Biol Chem. 2004 Oct 22;279(43):45257-65
pubmed: 15304479
Lab Invest. 2007 Jun;87(6):591-601
pubmed: 17334410
Science. 2003 Nov 28;302(5650):1571-5
pubmed: 14645851
Liver Res. 2019 Mar;3(1):55-64
pubmed: 32670671
Z Gastroenterol. 2007 Jan;45(1):35-41
pubmed: 17236119
J Biol Chem. 2014 Oct 24;289(43):29751-65
pubmed: 25170079
Nature. 2006 Aug 10;442(7103):700-4
pubmed: 16799563
Cancer Cell. 2014 Sep 8;26(3):331-343
pubmed: 25132496
Hepatology. 2014 Jan;59(1):154-69
pubmed: 23832448
Annu Rev Cell Dev Biol. 2010;26:157-77
pubmed: 19575662
Am J Physiol. 1997 Jan;272(1 Pt 2):R142-7
pubmed: 9039002
Lab Invest. 2003 May;83(5):655-63
pubmed: 12746475
Immunity. 2019 Apr 16;50(4):892-906
pubmed: 30995505
Cell Metab. 2006 Sep;4(3):185-98
pubmed: 16950136
Cell. 2018 Sep 20;175(1):133-145.e15
pubmed: 30220454
Gastroenterology. 2010 Feb;138(2):705-14, 714.e1-4
pubmed: 19843474
Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13656-61
pubmed: 10570128
Br J Pharmacol. 2009 Aug;157(8):1354-67
pubmed: 19594758
Cell Mol Life Sci. 2016 Jan;73(1):79-94
pubmed: 26433683
Oncoimmunology. 2016 Nov 18;6(1):e1258505
pubmed: 28197379
J Clin Invest. 2005 May;115(5):1343-51
pubmed: 15864352
Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3155-60
pubmed: 12624180
J Clin Invest. 2012 May;122(5):1677-87
pubmed: 22466652
Endocrinology. 2009 Dec;150(12):5384-94
pubmed: 19808779
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1832-7
pubmed: 19181853
Hepatology. 2014 Jul;60(1):334-48
pubmed: 24619965
Genes Dev. 1998 Jun 15;12(12):1812-24
pubmed: 9637683
Cell. 2002 Aug 23;110(4):489-500
pubmed: 12202038
Elife. 2017 Oct 03;6:
pubmed: 28971800
Exp Mol Med. 2020 May;52(5):724-729
pubmed: 32385422
J Cell Sci. 2009 May 15;122(Pt 10):1626-36
pubmed: 19420237