Effectiveness of endoscopic screening for gastric cancer: The Japan Public Health Center-based Prospective Study.
endoscopic screening
gastric cancer
population-based prospective cohort study
radiographic screening
Journal
Cancer science
ISSN: 1349-7006
Titre abrégé: Cancer Sci
Pays: England
ID NLM: 101168776
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
revised:
08
08
2022
received:
06
06
2022
accepted:
10
08
2022
pubmed:
25
8
2022
medline:
8
11
2022
entrez:
24
8
2022
Statut:
ppublish
Résumé
Upper gastrointestinal endoscopy for gastric cancer screening has been implemented in Japan. However, its effectiveness for gastric cancer prevention has not been fully studied. We aimed to investigate the effectiveness of endoscopic screening to reduce mortality from gastric cancer. In a large prospective population-based cohort study including 80,272 participants, we compared the risk of mortality and incidence of gastric cancer among participants who underwent endoscopic or radiographic screening compared with those who did not undergo any screening using multivariable Cox proportional hazards models. In the 1,023,364 person-year observation period (median; 13.0 years), 1977 cases of gastric cancer were diagnosed, and 783 patients with gastric cancer died. In the endoscopic screening group, the mortality from gastric cancer and incidence of advanced gastric cancer were reduced by 61% (hazard ratio [HR] = 0.39 [95% CI: 0.30-0.51]) and 22% (HR = 0.78 [95% CI: 0.67-0.90]), respectively. The radiographic screening reduced the mortality from gastric cancer (HR = 0.63 [95% CI: 0.54-0.73]), but its effectiveness was lower than that of endoscopic screening. In conclusion, endoscopic screening reduced the incidence of advanced gastric cancer and mortality from gastric cancer in the Japanese population.
Identifiants
pubmed: 36002149
doi: 10.1111/cas.15545
pmc: PMC9633299
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3922-3931Subventions
Organisme : Grant-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare of Japan
Organisme : National Cancer Center Research and Development Fund
Informations de copyright
© 2022 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.
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