BCR-Associated Protein 31 Regulates Macrophages Polarization and Wound Healing Function via Early Growth Response 2/C/EBPβ and IL-4Rα/C/EBPβ Pathways.
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 09 2022
15 09 2022
Historique:
received:
18
01
2022
accepted:
11
07
2022
pubmed:
25
8
2022
medline:
24
9
2022
entrez:
24
8
2022
Statut:
ppublish
Résumé
The BCR-associated protein 31 (BAP31), a transmembrane protein in the endoplasmic reticulum, participates in the regulation of immune cells, such as microglia and T cells, and has potential functions in macrophages that remain to be unexplored. In this study, we designed and bred macrophage-specific BAP31 knockdown mice to detect the polarization and functions of macrophages. The results revealed that M2 macrophage-associated genes were suppressed in mouse bone marrow-derived macrophages of Lyz2 Cre-BAP31
Identifiants
pubmed: 36002233
pii: jimmunol.2200044
doi: 10.4049/jimmunol.2200044
doi:
Substances chimiques
Bcap31 protein, mouse
0
CCAAT-Enhancer-Binding Protein-beta
0
Early Growth Response Protein 2
0
Egr2 protein, mouse
0
Il4ra protein, mouse
0
Membrane Proteins
0
Receptors, Cell Surface
0
Proteasome Endopeptidase Complex
EC 3.4.25.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1059-1070Informations de copyright
Copyright © 2022 by The American Association of Immunologists, Inc.