Clusters of risk factors in metabolic syndrome and their influence on central blood pressure in a global study.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 08 2022
24 08 2022
Historique:
received:
20
10
2021
accepted:
05
08
2022
entrez:
24
8
2022
pubmed:
25
8
2022
medline:
27
8
2022
Statut:
epublish
Résumé
The effect of metabolic syndrome (MetS) and clusters of its components on central blood pressure (CBP) has not been well characterized. We aimed to describe the effect of MetS and clusters of its components on CBP in a large population and to identify whether this effect differs in men and women. We studied 15,609 volunteers (43% women) from 10 cohorts worldwide who participated in the Metabolic syndrome and Artery REsearch Consortium. MetS was defined according to the NCEP-ATP III criteria (GHTBW, glucose, high-density lipoprotein cholesterol, triglyceride, blood pressure, waist circumference). CBP was measured noninvasively and acquired from pulse wave analysis by applanation tonometry. MetS was associated with a 50% greater odds of having higher CSBP. After controlling for age, male sex, non HDL cholesterol, diabetes mellitus, and mean arterial pressure, only specific clusters of MetS components were associated with a higher CSBP; and some of them were significant in women but not in men. We identified "risky clusters" of MetS variables associated with high CSBP. Future studies are needed to confirm they identify subjects at high risk of accelerated arterial aging and, thus, need more intensive clinical management.
Identifiants
pubmed: 36002468
doi: 10.1038/s41598-022-18094-y
pii: 10.1038/s41598-022-18094-y
pmc: PMC9402529
doi:
Substances chimiques
Blood Glucose
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Intramural
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
14409Subventions
Organisme : NIA NIH HHS
ID : N01AG12109
Pays : United States
Informations de copyright
© 2022. The Author(s).
Références
PLoS Genet. 2012;8(5):e1002695
pubmed: 22589738
J Hypertens. 2015 Jul;33(7):1438-45
pubmed: 25827429
Trends Endocrinol Metab. 2020 Mar;31(3):205-217
pubmed: 31843490
Atherosclerosis. 2012 Mar;221(1):189-97
pubmed: 22222417
J Am Med Dir Assoc. 2020 Jun;21(6):720-725
pubmed: 31884052
Atherosclerosis. 2014 Apr;233(2):654-660
pubmed: 24561493
J Am Coll Cardiol. 2010 Mar 30;55(13):1318-27
pubmed: 20338492
Eur Heart J. 2014 Nov 21;35(44):3122-33
pubmed: 25112663
Diabetol Metab Syndr. 2014 Feb 26;6(1):26
pubmed: 24568287
Atherosclerosis. 2011 Apr;215(2):459-64
pubmed: 21241986
Diabetol Metab Syndr. 2017 Jun 28;9:49
pubmed: 28670347
Hypertension. 2007 Jul;50(1):197-203
pubmed: 17485598
J Hypertens. 2020 Jan;38(1):21-29
pubmed: 31790375
Atherosclerosis. 2016 Dec;255:11-16
pubmed: 27794213
J Am Coll Cardiol. 1997 Dec;30(7):1863-71
pubmed: 9385920
Circulation. 2006 Mar 7;113(9):1213-25
pubmed: 16476843
Hypertension. 2001 Dec 1;38(6):1471-5
pubmed: 11751738
Science. 2019 Nov 1;366(6465):576-578
pubmed: 31672885
J Am Soc Hypertens. 2013 Sep-Oct;7(5):379-85
pubmed: 23850194
Chest. 1992 Oct;102(4):1193-8
pubmed: 1395767
Hypertension. 1999 Aug;34(2):217-21
pubmed: 10454444
Hypertension. 2010 Jun;55(6):1314-22
pubmed: 20404219
Hypertens Res. 2012 Mar;35(3):329-33
pubmed: 22158112
J Am Coll Cardiol. 2008 Jun 24;51(25):2432-9
pubmed: 18565402
J Alzheimers Dis. 2014;42 Suppl 4:S401-10
pubmed: 25182740
Hypertension. 2016 Jan;67(1):183-90
pubmed: 26597821
Eur Heart J. 2007 Jun;28(12):1462-536
pubmed: 17562668
JAMA. 2001 May 16;285(19):2486-97
pubmed: 11368702
Ann Intern Med. 2004 Jun 15;140(12):992-1000
pubmed: 15197016
Int J Cardiol. 2018 Jul 15;263:132-137
pubmed: 29754908
J Hypertens. 2009 Mar;27(3):461-7
pubmed: 19330899
Int J Exp Pathol. 2006 Dec;87(6):425-36
pubmed: 17222210
Aging Clin Exp Res. 2020 May;32(5):781-788
pubmed: 31302897
J Hypertens. 2018 Dec;36(12):2340-2349
pubmed: 30063641
J Hypertens. 2003 May;21(5):821-48
pubmed: 12714851
Eur Heart J. 2010 Oct;31(19):2338-50
pubmed: 20530030
J Hypertens. 2021 Jan;39(1):90-100
pubmed: 33273363
Lancet. 2016 Jan 30;387(10017):435-43
pubmed: 26559744