Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation.
Acetylmuramyl-Alanyl-Isoglutamine
/ chemistry
Animals
Bacteria
/ chemistry
Cell Wall
/ chemistry
Hexosamines
/ biosynthesis
Immunity, Innate
Macrophages
/ enzymology
Mice
Nod2 Signaling Adaptor Protein
/ agonists
Peptidoglycan
/ chemistry
Phosphorylation
Phosphotransferases (Alcohol Group Acceptor)
/ deficiency
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
19
02
2021
accepted:
20
07
2022
pubmed:
25
8
2022
medline:
20
9
2022
entrez:
24
8
2022
Statut:
ppublish
Résumé
Bacterial cell wall components provide various unique molecular structures that are detected by pattern recognition receptors (PRRs) of the innate immune system as non-self. Most bacterial species form a cell wall that consists of peptidoglycan (PGN), a polymeric structure comprising alternating amino sugars that form strands cross-linked by short peptides. Muramyl dipeptide (MDP) has been well documented as a minimal immunogenic component of peptidoglycan
Identifiants
pubmed: 36002575
doi: 10.1038/s41586-022-05125-x
pii: 10.1038/s41586-022-05125-x
pmc: PMC9477735
doi:
Substances chimiques
Hexosamines
0
Nod2 Signaling Adaptor Protein
0
Nod2 protein, mouse
0
Peptidoglycan
0
Acetylmuramyl-Alanyl-Isoglutamine
53678-77-6
Phosphotransferases (Alcohol Group Acceptor)
EC 2.7.1.-
N-acetylglucosamine kinase
EC 2.7.1.59
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
590-596Informations de copyright
© 2022. The Author(s).
Références
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