Impact of tricuspid valve insufficiency on the performance of left ventricular assist devices.
CO, cardiac output
CPB, cardiopulmonary bypass
CVP, central venous pressure
HF, heart failure
HR, heart rate
LVAD, left ventricular assist device
MAP, mean arterial pressure
PAPi, pulmonary artery pulsatility index
RV, right ventricular
RVF, right ventricle failure
TVI, tricuspid valve insufficiency
TVR, tricuspid valve reconstruction
animal model
bpm, beats per minute
coronary ligation
heart failure
mPAP, mean pulmonary artery pressure
ovine model
tricuspid regurgitation
tricuspid valve insufficiency
ventricular assist device
Journal
JTCVS open
ISSN: 2666-2736
Titre abrégé: JTCVS Open
Pays: Netherlands
ID NLM: 101768541
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
28
08
2020
accepted:
18
09
2020
entrez:
25
8
2022
pubmed:
24
9
2020
medline:
24
9
2020
Statut:
epublish
Résumé
To evaluate the impact of severe tricuspid valve insufficiency (TVI) at the time of left ventricular assist device (LVAD) implantation on the hemodynamic and LVAD parameters in an acute ovine model. Stable heart failure (HF) was induced in 10 ovines through the application of 3 ± 1 coronary ligations. Once stable HF was obtained (after 15 ± 5 days), the animals were supported with an LVAD. Hemodynamic data and pump parameters were obtained and compared in 2 settings; first with LVAD in place after weaning from the cardiopulmonary bypass machine (no TVI condition) and second following the induction of severe TVI through resection of the tricuspid valve (TVI condition). There were no statistically significant differences in the hemodynamic and pump parameters between TVI condition and no TVI conditions except for lower cardiac output in the TVI condition (2 [1.38-2.8] L/min vs 3.2 [1.55-3.7] L/min, Results from this acute animal study suggest that severe TVI in HF with preserved right ventricular function does not have significant impact on the LVAD pump parameters. The observed reduction in cardiac output may warrant further investigations, especially under loading conditions.
Identifiants
pubmed: 36004302
doi: 10.1016/j.xjon.2020.09.001
pii: S2666-2736(20)30107-8
pmc: PMC9390470
doi:
Types de publication
Journal Article
Langues
eng
Pagination
16-23Informations de copyright
© 2020 The Authors.
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