Diindolylmethane Derivatives: New Selective Blockers for T-Type Calcium Channels.
3,3′-diindolylmethane
T-type calcium channels
natural anticancer agent
selective blockers
Journal
Membranes
ISSN: 2077-0375
Titre abrégé: Membranes (Basel)
Pays: Switzerland
ID NLM: 101577807
Informations de publication
Date de publication:
30 Jul 2022
30 Jul 2022
Historique:
received:
18
07
2022
revised:
28
07
2022
accepted:
28
07
2022
entrez:
25
8
2022
pubmed:
26
8
2022
medline:
26
8
2022
Statut:
epublish
Résumé
The natural product indole-3-carbinol (I3C) and its major digestive product 3,3'-diindolylmethane (DIM) have shown clinical promise in multiple forms of cancer including breast cancer. In this study, we explored the calcium channel activity of DIM, its synthetic derivative 3,3'-Diindolylmethanone (DIM-one) and related I3C and DIM-one analogs. For the first time, DIM, DIM-one and analog IX were identified as selective blockers for T-type Ca
Identifiants
pubmed: 36005664
pii: membranes12080749
doi: 10.3390/membranes12080749
pmc: PMC9412534
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Health and Medical Research Council
ID : APP1072113
Organisme : Natural Science Foundation of the Higher Education Institutions of Jiangsu Province
ID : 21KJB350023
Organisme : Innovative and Entrepreneurial Program of Jiangsu Province
ID : JSSCBS20210960
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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