Vanillic acid attenuates cell proliferation, xenobiotic enzyme activity, and the status of pulmonary mitochondrial enzymes in lung carcinoma.
inflammation
lung cancer
lysosomal enzymes
proliferation
xenobiotic enzymes
Journal
Journal of food biochemistry
ISSN: 1745-4514
Titre abrégé: J Food Biochem
Pays: United States
ID NLM: 7706045
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
revised:
28
06
2022
received:
16
02
2022
accepted:
19
07
2022
pubmed:
26
8
2022
medline:
13
10
2022
entrez:
25
8
2022
Statut:
ppublish
Résumé
The purpose of the study is to determine the anti-proliferative and mitochondrial status of benzo(a)pyrene-induced lung cancer in Swiss albino mice, as well as the modulatory effect of vanillic acid on it. B(a)P had altered levels of lysosomal enzymes, xenobiotic-metabolizing enzymes, cell proliferation, inflammation, and mitochondrial abnormalities, whereas treatment with VA treatment significantly reversed the aforementioned activities. According to the findings, VA greatly reduces lung carcinogenesis by restoring antioxidants and xenobiotic-enzyme levels, consequently proving to be an anti-proliferative and anti-inflammatory drug against lung cancer in mice. PRACTICAL APPLICATIONS: As we all know, lung cancer is on the rise all over the world. A recent study demonstrated that vanillic acid protects against B(a)P in experimental mice. According to the findings, VA considerably suppresses lung carcinogenesis by restoring lysosomal enzyme levels, xenobiotic-metabolizing enzyme levels, and mitochondrial activities, effectively functioning as an anti-proliferative and anti-inflammatory therapy against lung cancer. According to the most recent study, vanillic acid can be used as a defensive medicine in the treatment of lung cancer.
Substances chimiques
Anticarcinogenic Agents
0
Xenobiotics
0
Benzo(a)pyrene
3417WMA06D
Vanillic Acid
GM8Q3JM2Y8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14366Informations de copyright
© 2022 Wiley Periodicals LLC.
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