Bisphenol S Impairs Oestradiol Secretion during In Vitro Basal Folliculogenesis in a Mono-Ovulatory Species Model.
bisphenols
endocrine disruptors
ewe
follicular growth
gene expression
hormonal secretions
ovary
plasticiser
Journal
Toxics
ISSN: 2305-6304
Titre abrégé: Toxics
Pays: Switzerland
ID NLM: 101639637
Informations de publication
Date de publication:
30 Jul 2022
30 Jul 2022
Historique:
received:
08
07
2022
revised:
25
07
2022
accepted:
27
07
2022
entrez:
25
8
2022
pubmed:
26
8
2022
medline:
26
8
2022
Statut:
epublish
Résumé
Bisphenol S (BPS) affects terminal folliculogenesis by impairing steroidogenesis in granulosa cells from different species. Nevertheless, limited data are available on its effects during basal folliculogenesis. In this study, we evaluate in vitro the effects of a long-term BPS exposure on a model of basal follicular development in a mono-ovulatory species. We cultured ovine preantral follicles (180−240 μm, n = 168) with BPS (0.1 μM (possible human exposure dose) or 10 μM (high dose)) and monitored antrum appearance and follicular survival and growth for 15 days. We measured hormonal secretions (oestradiol (at day 13 [D13]), progesterone and anti-Müllerian hormone [D15]) and expression of key follicular development and redox status genes (D15) in medium and whole follicles, respectively. BPS (0.1 µM) decreased oestradiol secretion compared with the control (−48.8%, p < 0.001), without significantly impairing antrum appearance, follicular survival and growth, anti-Müllerian hormone and progesterone secretion and target gene expression. Thus, BPS could also impair oestradiol secretion during basal folliculogenesis as it is the case during terminal folliculogenesis. It questions the use of BPS as a safe BPA substitute in the human environment. More studies are required to elucidate mechanisms of action of BPS and its effects throughout basal follicular development.
Identifiants
pubmed: 36006116
pii: toxics10080437
doi: 10.3390/toxics10080437
pmc: PMC9412475
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : French National Research Agency (ANR)
ID : ANR-18-CE34-0011-01 MAMBO
Organisme : Region Centre-Val de Loire
ID : APR IA 2019-00134937 PERFIDE
Références
Biochim Biophys Acta. 2016 Jul;1857(7):902-14
pubmed: 26921811
Environ Health Perspect. 2016 Apr;124(4):437-44
pubmed: 26309242
Mitochondrion. 2014 Nov;19 Pt A:20-8
pubmed: 24933571
Toxicol Appl Pharmacol. 2021 Sep 1;426:115634
pubmed: 34174261
Chemosphere. 2021 Feb;264(Pt 1):128445
pubmed: 33017704
Sci Total Environ. 2020 Jun 25;723:137952
pubmed: 32213405
Ecotoxicol Environ Saf. 2022 Jan 1;229:113096
pubmed: 34952380
Front Endocrinol (Lausanne). 2022 May 24;13:892213
pubmed: 35685208
Ann Occup Environ Med. 2020 Mar 05;32:e10
pubmed: 32411375
Reproduction. 2018 Jul;156(1):47-57
pubmed: 29748175
Environ Res. 2020 Apr;183:108944
pubmed: 31911000
Epigenetics. 2016 Jul 2;11(7):489-500
pubmed: 27267941
Environ Int. 2020 May;138:105644
pubmed: 32179324
BMC Endocr Disord. 2018 Nov 6;18(1):81
pubmed: 30400886
Chemosphere. 2018 Oct;209:508-516
pubmed: 29940534
Biores Open Access. 2017 Aug 01;6(1):104-109
pubmed: 29082109
Environ Sci Technol. 2021 Feb 2;55(3):1953-1963
pubmed: 33496180
Reprod Biol Endocrinol. 2021 Aug 3;19(1):119
pubmed: 34344364
J Ovarian Res. 2017 Nov 9;10(1):74
pubmed: 29122003
Int J Environ Res Public Health. 2021 Feb 04;18(4):
pubmed: 33557243
Int J Mol Sci. 2020 Aug 11;21(16):
pubmed: 32796699
Reproduction. 2017 May;153(5):493-508
pubmed: 28154111
Int J Mol Sci. 2020 Feb 12;21(4):
pubmed: 32059612
Rev Environ Health. 2020 Jun 25;35(2):201-210
pubmed: 31743105
Endocrinology. 2015 Jan;156(1):301-13
pubmed: 25322464
Toxicol In Vitro. 2017 Jun;41:143-149
pubmed: 28259788
Sci Total Environ. 2018 Feb 15;615:87-98
pubmed: 28963899
Reprod Toxicol. 2017 Oct;73:280-291
pubmed: 28676390
Toxicol Appl Pharmacol. 2013 Oct 1;272(1):127-36
pubmed: 23714657
Dis Markers. 2007;23(1-2):121-37
pubmed: 17325432
Reprod Toxicol. 2007 Apr-May;23(3):337-52
pubmed: 17140764
Reprod Fertil Dev. 2012;25(1):1-16
pubmed: 23244824
Vitam Horm. 2018;107:155-175
pubmed: 29544629
Toxicol In Vitro. 2012 Aug;26(5):727-31
pubmed: 22507746
J Endocrinol. 2017 Apr;233(1):R1-R13
pubmed: 28130407
Ecotoxicol Environ Saf. 2021 Jan 1;207:111299
pubmed: 32927158
Reprod Domest Anim. 2018 Apr;53(2):450-457
pubmed: 29330967
Sci Rep. 2022 Apr 19;12(1):5452
pubmed: 35440735
Sci Total Environ. 2022 Apr 1;815:152734
pubmed: 34973319
Toxicol Sci. 2019 Apr 1;168(2):561-571
pubmed: 30629253
Reprod Toxicol. 2020 Apr;93:19-27
pubmed: 31881267
Sci Total Environ. 2022 May 20;822:153548
pubmed: 35114227
Front Oncol. 2020 May 29;10:712
pubmed: 32670863
Regul Toxicol Pharmacol. 2018 Feb;92:138-144
pubmed: 29199064
PLoS One. 2013;8(1):e55387
pubmed: 23359474
Mol Hum Reprod. 2004 Feb;10(2):77-83
pubmed: 14742691
Sci Total Environ. 2020 Mar 10;707:136100
pubmed: 31863985
Cells. 2019 Sep 21;8(10):
pubmed: 31546660
Endocr Rev. 2000 Apr;21(2):200-14
pubmed: 10782364
Cells. 2020 Apr 17;9(4):
pubmed: 32316494
Integr Environ Assess Manag. 2022 Mar 31;:
pubmed: 35362236
Reprod Toxicol. 2021 Jan;99:96-108
pubmed: 33285269
Int J Clin Exp Pathol. 2018 Jul 01;11(7):3375-3382
pubmed: 31949714
Environ Sci Technol. 2012 Aug 21;46(16):9138-45
pubmed: 22784190
Curr Opin Obstet Gynecol. 2005 Jun;17(3):249-53
pubmed: 15870558
Reprod Biol Endocrinol. 2018 Aug 20;16(1):80
pubmed: 30126412
Int J Mol Sci. 2020 Mar 06;21(5):
pubmed: 32155818
Sci Total Environ. 2021 May 25;789:148013
pubmed: 34323825
Endocrinology. 2021 Mar 1;162(3):
pubmed: 33516155
Reproduction. 2020 May;159(5):571-583
pubmed: 32092037
Int J Mol Sci. 2022 Apr 11;23(8):
pubmed: 35457054
Environ Int. 2020 Dec;145:106078
pubmed: 32911243
Physiol Res. 2020 Dec 22;69(6):947-965
pubmed: 33129245
Chemosphere. 2020 Aug;253:126707
pubmed: 32289607
Environ Pollut. 2020 Dec;267:115382
pubmed: 32866863
Antioxidants (Basel). 2020 May 10;9(5):
pubmed: 32397641
Int J Hyg Environ Health. 2011 Sep;214(5):339-47
pubmed: 21570349
Chemosphere. 2020 Aug;252:126525
pubmed: 32220717
J Reprod Fertil Suppl. 1997;51:3-23
pubmed: 9404267
Domest Anim Endocrinol. 2019 Jan;66:48-56
pubmed: 30439591
J Environ Manage. 2012 Aug 15;104:19-34
pubmed: 22481365
Environ Sci Technol. 2017 Sep 5;51(17):9940-9949
pubmed: 28759207
Antioxidants (Basel). 2022 Feb 18;11(2):
pubmed: 35204295
Environ Health. 2021 May 15;20(1):60
pubmed: 33992119
Reprod Toxicol. 2021 Aug;103:18-27
pubmed: 34019995
Sci Rep. 2017 Mar 28;7(1):485
pubmed: 28352085
Mol Cell Endocrinol. 2013 Jul 5;373(1-2):8-20
pubmed: 23084976
Nutrients. 2020 Feb 19;12(2):
pubmed: 32092919
Chemosphere. 2018 Apr;197:336-343
pubmed: 29407803
Environ Res. 2019 Nov;178:108726
pubmed: 31539821
Ecotoxicol Environ Saf. 2019 May 15;172:444-450
pubmed: 30735977
Int J Mol Sci. 2022 Jan 03;23(1):
pubmed: 35008938
Environ Health Perspect. 2015 Jul;123(7):643-50
pubmed: 25775505
Biol Reprod. 2010 Nov;83(5):698-706
pubmed: 20631400
Toxicol Mech Methods. 2020 Jan;30(1):60-72
pubmed: 31424294
JBRA Assist Reprod. 2015 Nov 01;19(4):241-51
pubmed: 27203200