Humoral immunity to SARS-CoV-2 elicited by combination COVID-19 vaccination regimens.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
03 10 2022
03 10 2022
Historique:
received:
11
05
2022
revised:
19
06
2022
accepted:
13
07
2022
entrez:
25
8
2022
pubmed:
26
8
2022
medline:
30
8
2022
Statut:
ppublish
Résumé
The SARS-CoV-2 pandemic prompted a global vaccination effort and the development of numerous COVID-19 vaccines at an unprecedented scale and pace. As a result, current COVID-19 vaccination regimens comprise diverse vaccine modalities, immunogen combinations, and dosing intervals. Here, we compare vaccine-specific antibody and memory B cell responses following two-dose mRNA, single-dose Ad26.COV.2S, and two-dose ChAdOx1, or combination ChAdOx1/mRNA vaccination. Plasma-neutralizing activity, as well as the magnitude, clonal composition, and antibody maturation of the RBD-specific memory B cell compartments, showed substantial differences between the vaccination regimens. While individual monoclonal antibodies derived from memory B cells exhibited similar binding affinities and neutralizing potency against Wuhan-Hu-1 SARS-CoV-2, there were significant differences in epitope specificity and neutralizing breadth against viral variants of concern. Although the ChAdOx1 vaccine was inferior to mRNA and Ad26.COV.2S in several respects, biochemical and structural analyses revealed enrichment in a subgroup of memory B cell neutralizing antibodies with distinct RBD-binding properties resulting in remarkable potency and breadth.
Identifiants
pubmed: 36006380
pii: 213420
doi: 10.1084/jem.20220826
pmc: PMC9418484
pii:
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
COVID-19 Vaccines
0
RNA, Messenger
0
Viral Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Federal Institute for Drugs and Medical Devices
ID : V-2021.3/1503_68403/2021-2022
Organisme : Bulgari Women and Science Fellowship
Organisme : NCATS NIH HHS
ID : UL1 TR001866
Pays : United States
Organisme : Deutsche Forschungsgemeinschaft
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI138938
Pays : United States
Organisme : Charité Universitätsmedizin Berlin
Organisme : Shapiro-Silverberg Fund for the Advancement of Translational Research
Organisme : NIAID NIH HHS
ID : R37 AI064003
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI078788
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI165075
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001866
Pays : United States
Informations de copyright
© 2022 Wang et al.
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