Reproducibility of the energy metabolism response to an oral glucose tolerance test: influence of a postcalorimetric correction procedure.
Glucose tolerance
Indirect calorimetry
Metabolic cart
Postprandial metabolism
Reliability
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
20
05
2022
accepted:
03
08
2022
pubmed:
26
8
2022
medline:
8
2
2023
entrez:
25
8
2022
Statut:
ppublish
Résumé
Metabolic flexibility (MetF), which is a surrogate of metabolic health, can be assessed by the change in the respiratory exchange ratio (RER) in response to an oral glucose tolerance test (OGTT). We aimed to determine the day-to-day reproducibility of the energy expenditure (EE) and RER response to an OGTT, and whether a simulation-based postcalorimetric correction of metabolic cart readouts improves day-to-day reproducibility. The EE was assessed (12 young adults, 6 women, 27 ± 2 years old) using an Omnical metabolic cart (Maastricht Instruments, Maastricht, The Netherlands) after an overnight fast (12 h) and after a 75-g oral glucose dose on 2 separate days (48 h). On both days, we assessed EE in 7 periods (one 30-min baseline and six 15-min postprandial). The ICcE was performed immediately after each recording period, and capillary glucose concentration (using a digital glucometer) was determined. We observed a high day-to-day reproducibility for the assessed RER (coefficients of variation [CV] < 4%) and EE (CVs < 9%) in the 7 different periods. In contrast, the RER and EE areas under the curve showed a low day-to-day reproducibility (CV = 22% and 56%, respectively). Contrary to our expectations, the postcalorimetric correction procedure did not influence the day-to-day reproducibility of the energy metabolism response, possibly because the Omnical's accuracy was ~ 100%. Our study demonstrates that the energy metabolism response to an OGTT is poorly reproducible (CVs > 20%) even using a very accurate metabolic cart. Furthermore, the postcalorimetric correction procedure did not influence the day-to-day reproducibility. Trial registration NCT04320433; March 25, 2020.
Identifiants
pubmed: 36006468
doi: 10.1007/s00394-022-02986-w
pii: 10.1007/s00394-022-02986-w
pmc: PMC9899729
doi:
Substances chimiques
Glucose
IY9XDZ35W2
Blood Glucose
0
Banques de données
ClinicalTrials.gov
['NCT04320433']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
351-361Subventions
Organisme : Spanish Ministry of Education
ID : FPU15/04059
Informations de copyright
© 2022. The Author(s).
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