Molecular and cellular evolution of the primate dorsolateral prefrontal cortex.


Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
30 09 2022
Historique:
pubmed: 26 8 2022
medline: 4 10 2022
entrez: 25 8 2022
Statut: ppublish

Résumé

The granular dorsolateral prefrontal cortex (dlPFC) is an evolutionary specialization of primates that is centrally involved in cognition. We assessed more than 600,000 single-nucleus transcriptomes from adult human, chimpanzee, macaque, and marmoset dlPFC. Although most cell subtypes defined transcriptomically are conserved, we detected several that exist only in a subset of species as well as substantial species-specific molecular differences across homologous neuronal, glial, and non-neural subtypes. The latter are exemplified by human-specific switching between expression of the neuropeptide somatostatin and tyrosine hydroxylase, the rate-limiting enzyme in dopamine production in certain interneurons. The above molecular differences are also illustrated by expression of the neuropsychiatric risk gene

Identifiants

pubmed: 36007006
doi: 10.1126/science.abo7257
pmc: PMC9614553
mid: NIHMS1837719
doi:

Substances chimiques

Somatostatin 51110-01-1
Tyrosine 3-Monooxygenase EC 1.14.16.2
Dopamine VTD58H1Z2X

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabo7257

Subventions

Organisme : NINDS NIH HHS
ID : R24 NS092988
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG074341
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG010898
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG066165
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM141013
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH122678
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066508
Pays : United States
Organisme : NINDS NIH HHS
ID : F32 NS117780
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG059284
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA053628
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG058608
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH124619
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD105353
Pays : United States
Organisme : NIH HHS
ID : P51 OD011133
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM140935
Pays : United States
Organisme : NIH HHS
ID : P51 OD011106
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH116488
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG011641
Pays : United States

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Auteurs

Shaojie Ma (S)

Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.

Mario Skarica (M)

Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.

Qian Li (Q)

Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.

Chuan Xu (C)

Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.

Ryan D Risgaard (RD)

Waisman Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Medical Scientist Training Program, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.

Andrew T N Tebbenkamp (ATN)

Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.

Xoel Mato-Blanco (X)

Neurogenomics Group, Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), MELIS, Universitat Pompeu Fabra, 08003 Barcelona, Catalonia, Spain.

Rothem Kovner (R)

Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.

Željka Krsnik (Ž)

Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.
Croatian Institute for Brain Research, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.

Xabier de Martin (X)

Neurogenomics Group, Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), MELIS, Universitat Pompeu Fabra, 08003 Barcelona, Catalonia, Spain.

Victor Luria (V)

Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.

Xavier Martí-Pérez (X)

Neurogenomics Group, Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), MELIS, Universitat Pompeu Fabra, 08003 Barcelona, Catalonia, Spain.

Dan Liang (D)

Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.

Amir Karger (A)

IT-Research Computing, Harvard Medical School, Boston, MA, USA.

Danielle K Schmidt (DK)

Waisman Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.

Zachary Gomez-Sanchez (Z)

Waisman Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.

Cai Qi (C)

Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.

Kevin T Gobeske (KT)

Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale School of Medicine, New Haven, CT 06510, USA.

Sirisha Pochareddy (S)

Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.

Ashwin Debnath (A)

Waisman Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.

Cade J Hottman (CJ)

Waisman Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.

Joshua Spurrier (J)

Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Neurology, Yale School of Medicine, New Haven, CT 06536, USA.

Leon Teo (L)

Australian Regenerative Medicine Institute, 15 Innovation Walk, Monash University, Clayton, VIC 3800, Australia.

Anthony G Boghdadi (AG)

Australian Regenerative Medicine Institute, 15 Innovation Walk, Monash University, Clayton, VIC 3800, Australia.

Jihane Homman-Ludiye (J)

Australian Regenerative Medicine Institute, 15 Innovation Walk, Monash University, Clayton, VIC 3800, Australia.

John J Ely (JJ)

MAEBIOS, Alamogordo, NM 88310, USA.
Department of Anthropology and Center for the Advanced Study of Human Paleobiology, The George Washington University, Washington, DC, USA.

Etienne W Daadi (EW)

Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.

Da Mi (D)

Tsinghua-Peking Center for Life Sciences, IDG/McGovern Institute for Brain Research, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Marcel Daadi (M)

Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
Department of Cell Systems and Anatomy, Radiology, Long School of Medicine, UT Health, San Antonio, TX, USA.
NeoNeuron LLC, Palo Alto, CA 94306, USA.

Oscar Marín (O)

Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.
MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, UK.

Patrick R Hof (PR)

Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Mladen-Roko Rasin (MR)

Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.

James Bourne (J)

Australian Regenerative Medicine Institute, 15 Innovation Walk, Monash University, Clayton, VIC 3800, Australia.

Chet C Sherwood (CC)

Department of Anthropology and Center for the Advanced Study of Human Paleobiology, The George Washington University, Washington, DC, USA.

Gabriel Santpere (G)

Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.
Neurogenomics Group, Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), MELIS, Universitat Pompeu Fabra, 08003 Barcelona, Catalonia, Spain.

Matthew J Girgenti (MJ)

Department of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA.
National Center for PTSD, US Department of Veterans Affairs, White River Junction, VT, USA.

Stephen M Strittmatter (SM)

Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.
Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Neurology, Yale School of Medicine, New Haven, CT 06536, USA.
Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.

André M M Sousa (AMM)

Waisman Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.

Nenad Sestan (N)

Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.
Department of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA.
Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.
Departments of Genetics and Comparative Medicine, Program in Cellular Neuroscience, Neurodegeneration and Repair, and Yale Child Study Center, Yale School of Medicine, New Haven, CT 06510, USA.

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