Expression of DEspR in acute intracerebral hemorrhage.
Cerebral hemorrhage
Hemorrhagic stroke
Monocytes
Neutrophils
Journal
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
ISSN: 1532-8511
Titre abrégé: J Stroke Cerebrovasc Dis
Pays: United States
ID NLM: 9111633
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
16
03
2022
accepted:
24
07
2022
pubmed:
26
8
2022
medline:
28
9
2022
entrez:
25
8
2022
Statut:
ppublish
Résumé
Neuroinflammation and secondary injury play a central role in the pathophysiology of intracerebral hemorrhage. The dual endothelin-1/VEGFsignal-peptide receptor (DEspR) has been reported to mediate the inflammatory response after acute brain injury in a rodent model. We performed a pilot study to assess the expression of DEspR on circulating leukocytes in patients who presented with spontaneous intracerebral hemorrhage (ICH). We performed a prospective observational study of patients presenting to two academic medical centers with ICH. Normal healthy volunteers (NHV) were also recruited for sample analysis. Whole blood was obtained, and flow cytometry was performed to examine DEspR expression on neutrophils, monocytes, and lymphocytes. A total of 19 patients were included in analysis. Median ICH volume was 39 cm In this pilot study, DEspR is expressed on circulating neutrophils and monocytes in humans after ICH, with higher levels of expression in those with hypertension. Future work in larger cohorts should examine the relationship of DEspR expression with neuroinflammatory endpoints and long-term outcome.
Identifiants
pubmed: 36007264
pii: S1052-3057(22)00379-2
doi: 10.1016/j.jstrokecerebrovasdis.2022.106685
pmc: PMC9509454
mid: NIHMS1831934
pii:
doi:
Substances chimiques
Endothelin-1
0
Receptors, Peptide
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
106685Subventions
Organisme : NINDS NIH HHS
ID : R01 NS099209
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS120002
Pays : United States
Organisme : NINDS NIH HHS
ID : R61 NS112447
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
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