Disruption of the gene regulatory programme in neurodevelopmental disorders.
Cortical development
Epigenetics
Gene regulation
Genomics
Neurodevelopmental disorders
Journal
Biochimica et biophysica acta. Gene regulatory mechanisms
ISSN: 1876-4320
Titre abrégé: Biochim Biophys Acta Gene Regul Mech
Pays: Netherlands
ID NLM: 101731723
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
22
05
2022
revised:
10
08
2022
accepted:
12
08
2022
pubmed:
26
8
2022
medline:
12
10
2022
entrez:
25
8
2022
Statut:
ppublish
Résumé
Cortical development consists of a series of synchronised events, including fate transition of cortical progenitors, neuronal migration, specification and connectivity. It is becoming clear that gene expression programs governing these events rely on the interplay between signalling molecules, transcription factors and epigenetic mechanisms. When genetic or environmental factors disrupt expression of genes involved in important brain development processes, neurodevelopmental disorders can occur. This review aims to highlight how recent advances in technologies have helped uncover and imitate the gene regulatory mechanisms commonly disrupted in neurodevelopmental disorders.
Identifiants
pubmed: 36007842
pii: S1874-9399(22)00075-X
doi: 10.1016/j.bbagrm.2022.194860
pii:
doi:
Substances chimiques
Transcription Factors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
194860Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.