Arterial Stiffness and Chronic Kidney Disease Progression in Children.
arterial stiffness
children
chronic kidney disease
longitudinal studies
prospective studies
pulse wave velocity
Journal
Clinical journal of the American Society of Nephrology : CJASN
ISSN: 1555-905X
Titre abrégé: Clin J Am Soc Nephrol
Pays: United States
ID NLM: 101271570
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
19
02
2022
accepted:
27
07
2022
pubmed:
26
8
2022
medline:
14
1
2023
entrez:
25
8
2022
Statut:
ppublish
Résumé
CKD has been linked to increased arterial stiffness in adults, but data in children with CKD remain conflicting. We aimed to investigate the longitudinal dynamics and determinants of pulse wave velocity in children with CKD and its association with CKD progression. We performed an analysis of the Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) study, which prospectively followed children aged 6-17 years with CKD stages 3-5. Follow-up was censored at the time of KRT initiation. Two separate analyses were performed: with absolute pulse wave velocity (primary outcome) and with pulse wave velocity standardized to height ( In total, 667 patients with a mean baseline eGFR of 27 ml/min per 1.73 m Pulse wave velocity is increased in children with CKD but does not associate with eGFR or CKD progression.
Sections du résumé
BACKGROUND AND OBJECTIVES
CKD has been linked to increased arterial stiffness in adults, but data in children with CKD remain conflicting. We aimed to investigate the longitudinal dynamics and determinants of pulse wave velocity in children with CKD and its association with CKD progression.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS
We performed an analysis of the Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) study, which prospectively followed children aged 6-17 years with CKD stages 3-5. Follow-up was censored at the time of KRT initiation. Two separate analyses were performed: with absolute pulse wave velocity (primary outcome) and with pulse wave velocity standardized to height (
RESULTS
In total, 667 patients with a mean baseline eGFR of 27 ml/min per 1.73 m
CONCLUSIONS
Pulse wave velocity is increased in children with CKD but does not associate with eGFR or CKD progression.
Identifiants
pubmed: 36008353
pii: 01277230-202210000-00008
doi: 10.2215/CJN.02200222
pmc: PMC9528270
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1467-1476Informations de copyright
Copyright © 2022 by the American Society of Nephrology.
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